Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113095
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Chronic obstructive pulmonary disease (COPD) is a respiratory inflammatory disease. Unlike asthma, COPD is insensitive to glucocorticoid treatment; thus, it is of great importance to find alternative medications, including Chinese medicine, to suppress… read more here.
Keywords: signalling pathways; inflammation; pi3k akt; copd ... See more keywords
Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13432
Abstract: Several cereal grains contain a mycotoxin food contaminant called deoxynivalenol (DON), which presents a significant health risk as it is one of the most commonly found mycotoxins. The current paper examines the ameliorative effect of… read more here.
Keywords: mangiferin protect; stress; protect oxidative; endothelial cells ... See more keywords
Melanocyte‐protective effect of afzelin is mediated by the Nrf2‐ARE signalling pathway via GSK‐3β inactivation
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13277
Abstract: Vitiligo is an acquired condition characterized by depigmented, cutaneous lesions that result from the death of pigment‐producing cells, melanocytes. The occurrence of oxidative stress has been proposed as a pathogenetic mechanism for melanocyte degeneration in… read more here.
Keywords: mediated nrf2; via gsk; effect afzelin; afzelin ... See more keywords
Polydatin promotes the neuronal differentiation of bone marrow mesenchymal stem cells in vitro and in vivo: Involvement of Nrf2 signalling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15187
Abstract: Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising repair strategy following spinal cord injury (SCI), although the therapeutic effects are minimal due to their limited neural differentiation potential. Polydatin (PD), a key component… read more here.
Keywords: bone marrow; differentiation; nrf2 signalling; marrow mesenchymal ... See more keywords
4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17185
Abstract: Small molecule drug intervention for chondrocytes is a valuable method for the treatment of osteoarthritis (OA). The 4‐octyl itaconate (OI) is a cellular derivative of itaconate with sound cell permeability and transformation rate. We attempted… read more here.
Keywords: lipopolysaccharide lps; nrf2 signalling; octyl itaconate; signalling pathway ... See more keywords
Plumbagin ameliorates LPS‐induced acute lung injury by regulating PI3K/AKT/mTOR and Keap1‐Nrf2/HO‐1 signalling pathways
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18386
Abstract: Acute lung injury (ALI) is a major pathophysiological problem characterized by severe inflammation, resulting in high morbidity and mortality. Plumbagin (PL), a major bioactive constituent extracted from the traditional Chinese herb Plumbago zeylanica, has been… read more here.
Keywords: nrf2 signalling; akt mtor; keap1 nrf2; induced lps ... See more keywords
CAPG Regulates Doxorubicin Resistance in Hepatocellular Carcinoma Cells via TGFB1/Smad/Nrf2 Signalling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70847
Abstract: Hepatocellular carcinoma (HCC) is a common and deadly type of liver cancer with limited treatment options and a considerable issue with chemoresistance. This study investigates the role of the cytoskeleton‐associated protein G (CAPG) gene in… read more here.
Keywords: via tgfb1; resistance; nrf2 signalling; hcc ... See more keywords
Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/2360427
Abstract: Although gemcitabine is the standard chemotherapy treatment for advanced pancreatic cancer, its benefits are quite limited due to prevalent chemoresistance, and the mechanism underlying gemcitabine chemoresistance remains unclear. Currently, Nrf2 has been deemed as a… read more here.
Keywords: gemcitabine; brusatol; pancreatic cancer; cancer cells ... See more keywords
Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.865073
Abstract: Melanoma is an aggressive malignant skin tumour with an increasing global incidence. However, current treatments have limitations owing to the acquired tumour drug resistance. Ferroptosis is a recently discovered form of programmed cell death characterised… read more here.
Keywords: keap1 nrf2; melanoma; nrf2 signalling; melanoma cells ... See more keywords
Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076723
Abstract: Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive oxygen species… read more here.
Keywords: cardiovascular disease; nrf2 signalling; toxicity; factor ... See more keywords
Fucoxanthin Shields Vero Cells from H2O2-Induced Oxidative Damage by Potentially Activating the Nrf2 Signalling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2025.00164
Abstract: Background: Traditional herbal medicine has long made use of fucoxanthin, an important pigment present in edible brown seaweed. It is critical for immune system support and the regulation of reactive oxygen species (ROS) metabolism, both… read more here.
Keywords: nrf2 signalling; oxidative stress; h2o2 induced; vero cells ... See more keywords