KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction
Sign Up to like & getrecommendations! Published in 2024 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12595
Abstract: The average fatherhood age has been consistently increasing in developed countries. Aging has been identified as a risk factor for male infertility. However, its impact on various mechanisms remains unclear. This study focused on the… read more here.
Keywords: age; age related; nrf2 system; keap1 nrf2 ... See more keywords
NBR1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system
Sign Up to like & getrecommendations! Published in 2020 at "EMBO reports"
DOI: 10.15252/embr.201948902
Abstract: p62/SQSTM1 is a multivalent protein that has the ability to cause liquid–liquid phase separation and serves as a receptor protein that participates in cargo isolation during selective autophagy. This protein is also involved in the… read more here.
Keywords: keap1 nrf2; p62 sqstm1; nrf2 system; p62 liquid ... See more keywords
The KEAP1-NRF2 System in Healthy Aging and Longevity
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10121929
Abstract: Aging is inevitable, but the inherently and genetically programmed aging process is markedly influenced by environmental factors. All organisms are constantly exposed to various stresses, either exogenous or endogenous, throughout their lives, and the quality… read more here.
Keywords: keap1 nrf2; nrf2 system; system healthy; aging related ... See more keywords
Multifaceted Roles of the KEAP1–NRF2 System in Cancer and Inflammatory Disease Milieu
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11030538
Abstract: In a multicellular environment, many different types of cells interact with each other. The KEAP1–NRF2 system defends against electrophilic and oxidative stresses in various types of cells. However, the KEAP1–NRF2 system also regulates the expression… read more here.
Keywords: system; keap1 nrf2; roles keap1; nrf2 system ... See more keywords
Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11061112
Abstract: The nuclear factor erythroid 2-related factor 2 (Nrf2) protects the cell against oxidative damage. The Nrf2 system comprises a complex network that functions to ensure adequate responses to redox perturbations, but also metabolic demands and… read more here.
Keywords: nrf2 system; nrf2 activation; kidney; kidney disease ... See more keywords
The KEAP1-NRF2 System and Esophageal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194702
Abstract: Simple Summary NRF2-activated or NRF2-addicted cancers show high incidence, especially in esophageal squamous cell carcinoma (ESCC). ESCC with high NRF2 expression is largely resistant to the current major treatments for ESCC and therefore shows a… read more here.
Keywords: nrf2 system; system; keap1 nrf2; nrf2 addicted ... See more keywords
The Contribution of the Nrf2/ARE System to Mechanotransduction in Musculoskeletal and Periodontal Tissues
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097722
Abstract: Mechanosensing plays an essential role in maintaining tissue functions. Across the human body, several tissues (i.e., striated muscles, bones, tendons, ligaments, as well as cartilage) require mechanical loading to exert their physiological functions. Contrary, mechanical… read more here.
Keywords: nrf2 system; system; contribution nrf2; pathology ... See more keywords