Identification of novel Nrf2 target genes as prognostic biomarkers in colitis-associated colorectal cancer in Nrf2-deficient mice.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116968
Abstract: AIMS Colorectal cancer (CRC) is the third most common cancer worldwide. Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of many cytoprotective genes, plays a protective role in carcinogenesis. Recent studies have identified… read more here.
Keywords: target genes; colorectal cancer; mice; colitis associated ... See more keywords
Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
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DOI: 10.2147/dddt.s193889
Abstract: Background Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being evaluated in patients with Friedreich’s ataxia. Methods… read more here.
Keywords: omaveloxolone; friedreich ataxia; ataxia patients; oral administration ... See more keywords
BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma
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DOI: 10.3390/antiox11010114
Abstract: KELCH-ECH-associated protein 1 (KEAP1) is an adaptor protein of Cullin 3 (CUL3) E3 ubiquitin ligase that targets a redox sensitive transcription factor, NF-E2-related factor 2 (NRF2). BRCA1-associated protein 1 (BAP1) is a tumor suppressor and… read more here.
Keywords: target genes; lung adenocarcinoma; nrf2 target; keap1 ... See more keywords