Modulating Nrf2 transcription factor activity: Revealing the regulatory mechanisms of antioxidant defenses during hibernation in 13-lined ground squirrels.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3627
Abstract: Mammalian hibernators undergo major behavioural, physiological and biochemical changes to survive hypothermia, ischaemia-reperfusion and finite fuel reserves during days or weeks of continuous torpor. During hibernation, the 13-lined ground squirrel (Ictidomys tridecemlineatus) undergoes a global… read more here.
Keywords: transcription; nrf2 transcription; hibernation lined; antioxidant defenses ... See more keywords
Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01083-3
Abstract: Activator protein-1 (AP-1) plays a decisive role in cell proliferation, apoptosis, and inflammation under hypoxia; thus, AP-1 subunits or dimers could be modulated for a desired phenomenon in a cell using a suitable compound of… read more here.
Keywords: nrf2 transcription; cell survival; tan iia; tanshinone iia ... See more keywords
Carotenoids and Polyphenols Synergistically Balance Skin Response to UV (P02-007-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz029.p02-007-19
Abstract: Objectives To demonstrate that the combination of carotenoids and polyphenols produce a synergistic photo-protective effect from UV-induced damage to skin cells. Mechanistically, this can be partially explained by modulation of the NFkB and antioxidant response… read more here.
Keywords: response; combination; nrf2 transcription; carotenoids polyphenols ... See more keywords
Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20163856
Abstract: The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role in mediating the cellular stress response. Due to their antioxidant properties, compounds activating NRF2 have received much attention as potential medications for… read more here.
Keywords: wound healing; nrf2 transcription; regulation wound; transcription factor ... See more keywords
NRF2, a Transcription Factor for Stress Response and Beyond
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21134777
Abstract: Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2… read more here.
Keywords: nrf2 transcription; response; transcription factor; stress response ... See more keywords