Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer
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DOI: 10.1158/1078-0432.ccr-19-1280
Abstract: Approximately 8%–10% of pancreatic ductal adenocarcinoma cases are KRAS wild type. In a subset of these tumors, NRG1 gene fusions have been identified as targetable oncogenic drivers, a discovery that highlights the importance of deep… read more here.
Keywords: hope targeted; nrg1 fusions; cancer; fusions new ... See more keywords
Abstract 921: Identification of NRG1 fusions in patients with solid tumors: analysis from a real-world community oncology network
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DOI: 10.1158/1538-7445.am2023-921
Abstract: Neuregulin-1 (encoded by NRG1) serves as a ligand for ERBB3 and can lead to dysregulated cellular proliferation in cases of NRG1 fusions. The reported incidence of NRG1 fusions in solid tumors is ~0.1-0.3% with enrichment… read more here.
Keywords: oncology; fusion; community; nrg1 fusions ... See more keywords