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   Articles with "nrk 52e" as a keyword



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Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling

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recommendations! Published in 2019 at "Cytotechnology"

DOI: 10.1007/s10616-019-00335-0

Abstract: Oleanolic acid (OA), a potential drug for diabetic nephropathy (DN) treatment was found to downregulate the expression of microRNA (miR). The research aimed to investigate the effect of OA on autophagy mediated through miR-142-5p targeted… read more here.

Keywords: nrk 52e; mir 142; autophagy; 52e cells ... See more keywords
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Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.

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recommendations! Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2019.05.036

Abstract: Diabetic nephropathy (DN) is one of the most severe complications of diabetes mellitus. The pathomolecular events behind DN remain uncertain. Peroxisome proliferator-activated receptors (PPARs) play essential functions in the development of DN. Meanwhile, 20-hydroxyeicosatetraenoic acid… read more here.

Keywords: ppar antagonist; effects ppars; cyp4a hete; nrk 52e ... See more keywords
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Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation

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recommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"

DOI: 10.1080/08923973.2022.2039935

Abstract: Abstract Background Stevioside is a natural diterpenoid compound that possesses anti-inflammatory, immunomodulatory, anti-diabetic, anti-hypertensive, and renal protective effects, but its effect on lipopolysaccharide (LPS)-induced epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, an important immune… read more here.

Keywords: mesenchymal transition; nrk 52e; smad2; epithelial mesenchymal ... See more keywords
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Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling

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recommendations! Published in 2022 at "Free Radical Research"

DOI: 10.1080/10715762.2022.2032021

Abstract: Abstract Pyroptosis is an exceptional mode of inflammation and programmed cell death involved in inflammasomes and Caspase-1 activation and inflammatory cytokines releasing. Our goal is to explore whether uranium (U)-intoxication could induce NRK-52E cells pyroptosis… read more here.

Keywords: nlrp3 caspase; ros nlrp3; pyroptosis; nrk 52e ... See more keywords
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Effect of cell cycle synchronization on cadmium-induced apoptosis and necrosis in NRK-52E cells

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recommendations! Published in 2020 at "Cell Cycle"

DOI: 10.1080/15384101.2020.1848065

Abstract: ABSTRACT Heavy metal pollution is a problem that cannot be ignored. Due to the prevalence of cadmium in the environment and its harmful effects on humans, cadmium pollution has become a research hotspot recently. The… read more here.

Keywords: cadmium induced; nrk 52e; cell cycle; effect ... See more keywords
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Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR-218.

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recommendations! Published in 2020 at "Journal of cellular and molecular medicine"

DOI: 10.1111/jcmm.16129

Abstract: Circular RNAs play essential roles in the development of various human diseases. However, how circRNAs are involved in diabetic nephropathy (DN) are not fully understood. Our study aimed to investigate the effects of circRNA circEIF4G2… read more here.

Keywords: fibrosis; circular rna; nrk 52e; mir 218 ... See more keywords
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Mesenchymal Stem Cells Ameliorate Fibrosis by Enhancing Autophagy via Inhibiting Galectin-3/Akt/mTOR Pathway and by Alleviating the EMT via Inhibiting Galectin-3/Akt/GSK3β/Snail Pathway in NRK-52E Fibrosis

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recommendations! Published in 2022 at "International Journal of Stem Cells"

DOI: 10.15283/ijsc22014

Abstract: Background and Objectives Epithelial-Mesenchymal transition (EMT) is one of the origins of myofibroblasts in renal interstitial fibrosis. Mesenchymal stem cells (MSCs) alleviating EMT has been proved, but the concrete mechanism is unclear. To explore the… read more here.

Keywords: nrk 52e; via inhibiting; inhibiting galectin; pathway ... See more keywords
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Effects of homeodomain-interacting protein kinase 2 on renal tubular epithelial cells.

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recommendations! Published in 2020 at "European review for medical and pharmacological sciences"

DOI: 10.26355/eurrev_202006_21520

Abstract: OBJECTIVE To research the role of homeodomain-interacting protein kinase 2 (HIPK2) on the oxidative stress (OS) and apoptosis induced by hypoxia/reoxygenation (H/R) of normal rat kidney-52E (NRK-52E) cells, through the JAK2/STAT3 signaling pathway MATERIALS AND… read more here.

Keywords: homeodomain interacting; nrk 52e; 52e cells; protein kinase ... See more keywords
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Acidosis Activates the Nrf2 Pathway in Renal Proximal Tubule-Derived Cells through a Crosstalk with Renal Fibroblasts

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recommendations! Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12020412

Abstract: Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage. In order to… read more here.

Keywords: acidosis; nrk 52e; expression; nrf2 pathway ... See more keywords
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Epithelial–Fibroblast Crosstalk Protects against Acidosis-Induced Inflammatory and Fibrotic Alterations

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recommendations! Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10030681

Abstract: Pathogenesis of chronic kidney disease (CKD) is accompanied by extracellular acidosis inflammation, fibrosis and epithelial-to-mesenchymal transition (EMT). The aim of this study was to assess the influence of acidosis on tubule epithelial cells (NRK-52E) and… read more here.

Keywords: acidosis; acidosis led; nrk 52e; crosstalk ... See more keywords
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Suppression of CIP4/Par6 attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells

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recommendations! Published in 2017 at "International Journal of Molecular Medicine"

DOI: 10.3892/ijmm.2017.3100

Abstract: Transforming growth factor-β (TGF-β) induces epithelial-mesenchymal transition (EMT) primarily via a Smad-dependent mechanism. However, there are few studies available on TGF-β-induced EMT through the activation of non-canonical pathways. In this study, the Cdc42-interacting protein-4 (CIP4)/partitioning-defective… read more here.

Keywords: nrk 52e; cip4; tgf; expression ... See more keywords