Discovery of dual S-RBD/NRP1-targeting peptides: structure-based virtual screening, synthesis, biological evaluation, and molecular dynamics simulation studies
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2212327
Abstract: Abstract Both receptor-binding domain in spike protein (S-RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human neuropilin-1 (NRP1) are important in the virus entry, and their concomitant inhibition may become a potential strategy… read more here.
Keywords: nrp1 targeting; nrp1; dual rbd; rbd nrp1 ... See more keywords
Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection In Vitro
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DOI: 10.1128/aac.00695-20
Abstract: We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but… read more here.
Keywords: decoy receptor; receptor; nrp1; effect neuropilin ... See more keywords
Neuropilin 1 Involvement in Choroidal and Retinal Neovascularisation
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DOI: 10.1371/journal.pone.0169865
Abstract: Purpose Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin… read more here.
Keywords: retinal neovascularisation; nrp1; neuropilin involvement; choroidal retinal ... See more keywords
NRP1-positive lung cancer cells possess tumor-initiating properties
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DOI: 10.3892/or.2017.6089
Abstract: Tumor-initiating cells possess the capacity for self-renewal and to create heterogeneous cell lineages within a tumor. Therefore, the identification and isolation of cancer stem cells is an essential step in the analysis of their biology.… read more here.
Keywords: nrp1; tumor initiating; lung cancer; cancer ... See more keywords