Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918759117
Abstract: Significance Nonribosomal peptides (NRPs) are a vast class of natural products and an important source of therapeutics. Typically, these secondary metabolites are assembled by NRP synthetases (NRPSs) that function on substrates covalently linked to the… read more here.
Keywords: unusual thiotemplated; atp grasp; secondary metabolites; nrps independent ... See more keywords
Discovery, functional characterization, and structural studies of the NRPS-independent siderophore synthetases
Sign Up to like & getrecommendations! Published in 2024 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2025.2476476
Abstract: Abstract To adapt to low-iron environments, many bacteria produce siderophores, low molecular weight iron chelators that are secreted into the environment where they bind ferric iron. The production of siderophore uptake systems then allows retrieval… read more here.
Keywords: family; characterization structural; iron; nrps independent ... See more keywords