Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy
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DOI: 10.1073/pnas.1918759117
Abstract: Significance Nonribosomal peptides (NRPs) are a vast class of natural products and an important source of therapeutics. Typically, these secondary metabolites are assembled by NRP synthetases (NRPSs) that function on substrates covalently linked to the… read more here.
Keywords: unusual thiotemplated; atp grasp; secondary metabolites; nrps independent ... See more keywords