Generalized–ensemble method study: A helix‐mimetic compound inhibits protein–protein interaction by long‐range and short‐range intermolecular interactions
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26516
Abstract: A heterocyclic compound mS‐11 is a helix‐mimetic designed to inhibit binding of an intrinsic disordered protein neural restrictive silence factor/repressor element 1 silencing factor (NRSF/REST) to a receptor protein mSin3B. We apply a generalized ensemble… read more here.
Keywords: nrsf rest; ensemble method; range; helix mimetic ... See more keywords
NRSF regulates age-dependently cognitive ability and its conditional knockout in APP/PS1 mice moderately alters ad-like pathology.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac253
Abstract: NRSF/REST plays a key role in neuronal homeostasis as a transcriptional repressor of neuronal genes. NRSF/REST relates to cognitive preservation and longevity of humans, but its specific functions in age-dependent and Alzheimer's disease (ad)-related memory… read more here.
Keywords: app ps1; nrsf rest; age; pathology ... See more keywords