Production of Properly Folded NS1 Protein in Bacterial Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1879-0_3
Abstract: Dengue virus (DENV) NS1 protein is a multifunctional protein involved in several pathogenic processes but also has been described as a protective antigen suitable for eliciting humoral response against DENV. NS1 is essential for virus… read more here.
Keywords: protein; bacterial cells; production properly; properly folded ... See more keywords
Expression and Purification of Dengue NS1 Protein in Sf9-Baculovirus System.
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DOI: 10.1007/978-1-0716-1879-0_4
Abstract: It is well known that glycosylations of Dengue NS1 protein are important for its structure, oligomerization, and immunogenicity. One of the major challenges in heterologous NS1 protein expression is the difference in glycosylation patterns amongst different organisms.… read more here.
Keywords: protein; ns1 protein; dengue ns1; expression purification ... See more keywords
The NS1 Protein from Influenza Virus Stimulates Translation Initiation by Enhancing Ribosome Recruitment to mRNAs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.04.007
Abstract: The non-structural protein NS1 of influenza A viruses exerts pleiotropic functions during infection. Among these functions, NS1 was shown to be involved in the control of both viral and cellular translation; however, the mechanism by… read more here.
Keywords: ns1 protein; translation; protein influenza; influenza virus ... See more keywords
Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Virus research"
DOI: 10.1016/j.virusres.2017.07.021
Abstract: The influenza virus NS1 protein interacts with a wide range of proteins to suppress the host cell immune response and facilitate virus replication. The amino acid sequence of the 2009 pandemic virus NS1 protein differed… read more here.
Keywords: protein; position 171; ns1 protein; mutations position ... See more keywords
Virtual screening of small natural compounds against NS1 protein of DENV, YFV and ZIKV
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2042390
Abstract: Abstract Diseases caused by viruses of the genus Flavivirus are among the main diseases that affect the world and they are a serious public health problem. Three of them stand out: Dengue, Yellow fever and… read more here.
Keywords: yfv zikv; virtual screening; denv yfv; ns1 protein ... See more keywords
Bioinformatics Analysis of Mutations Sheds Light on the Evolution of Dengue NS1 Protein With Implications in the Identification of Potential Functional and Druggable Sites
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad033
Abstract: Abstract Non-structural protein (NS1) is a 350 amino acid long conserved protein in the dengue virus. Conservation of NS1 is expected due to its importance in dengue pathogenesis. The protein is known to exist in… read more here.
Keywords: structure; dengue; analysis; druggable sites ... See more keywords
Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00198-17
Abstract: ABSTRACT The RNA-dependent protein kinase (PKR) has broad antiviral activity inducing translational shutdown of viral and cellular genes and is therefore targeted by various viral proteins to facilitate pathogen propagation. The pleiotropic NS1 protein of… read more here.
Keywords: protein; virulence; ns1 protein; inhibition ... See more keywords
Association of viral kinetics, infection history, NS1 protein with plasma leakage among Indonesian dengue infected patients
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DOI: 10.1371/journal.pone.0285087
Abstract: Objectives Plasma leakage, a hallmark of disease in Dengue virus (DENV) infection, is an important clinical manifestation and is often associated with numerous factors such as viral factors. The aim of this study is to… read more here.
Keywords: infection; viral load; ns1 protein; plasma leakage ... See more keywords
Stability of Dengue 2 Nonstructural Glycoprotein 1 (NS1) Is Affected by the Nature of Basic Residue at Position NS1-324
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DOI: 10.3390/cimb45020106
Abstract: Dengue is the most prevalent mosquito-borne viral disease. It is caused by the infection of any of the four dengue virus (DENV) serotypes DENV-1 to DENV-4. The DENV non-structural glycoprotein 1 (NS1) plays an important… read more here.
Keywords: glycoprotein ns1; ns1 324; stability; ns1 protein ... See more keywords
Experimental Dengue Virus Type 4 Infection Increases the Expression of MicroRNAs-15/16, Triggering a Caspase-Induced Apoptosis Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45060291
Abstract: The World Health Organization has estimated the annual occurrence of approximately 392 million dengue virus (DENV) infections in more than 100 countries where the virus is endemic, which represents a serious threat to humanity. DENV… read more here.
Keywords: ns1 protein; dengue virus; infection; dengue ... See more keywords
Predicting Antigenic Peptides from Rocio Virus NS1 Protein for Immunodiagnostic Testing Using Immunoinformatics and Molecular Dynamics Simulation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147681
Abstract: The mosquito-borne disease caused by the Rocio virus is a neglected threat, and new immune inputs for serological testing are urgently required for diagnosis in low-resource settings and epidemiological surveillance. We used in silico approaches… read more here.
Keywords: molecular dynamics; ns1 protein; rocio virus; virus ... See more keywords