Zika virus NS2A and NS4A are the major antagonists that reduce IFN-β promoter activity induced by the MDA5/RIG-I signaling pathway.
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DOI: 10.4014/jmb.1909.09017
Abstract: Zika virus (ZIKV) is a mosquito-transmitted emerging Flavivirus causing the Guillain-Barré syndrome and microcephaly in adults and fetuses, respectively. Since ZIKV was first isolated in 1947, severe outbreaks have occurred at various places worldwide, including… read more here.
Keywords: promoter activity; rig; mda5 rig; ns2a ns4a ... See more keywords