Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104536
Abstract: Yellow fever virus (YFV) is responsible for devastating outbreaks of Yellow fever (YF) in humans and is associated with high mortality rates. Recent large epidemics and epizootics and exponential increases in the numbers of YF… read more here.
Keywords: yfv; yellow fever; fever; ns5 protein ... See more keywords
The rearrangement of motif F in the flavivirus RNA-directed RNA polymerase.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.11.009
Abstract: In the flavivirus genus, the non-structural protein NS5 plays a central role in RNA viral replication and constitutes a major target for drug discovery. One of the prime challenges in the study of NS5 protein… read more here.
Keywords: ns5 protein; flavivirus; rna polymerase;
Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2403235121
Abstract: Significance The ZIKA virus (ZIKV) subverts the innate immune response by degrading STAT2 via NS5 protein, crucial for evading antiviral defenses. However, the precise mechanism has remained elusive. Here, we elucidated ZSWIM8 as the substrate… read more here.
Keywords: ligase; degradation; interferon signaling; ns5 protein ... See more keywords