BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells
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DOI: 10.1007/s10549-017-4442-y
Abstract: PurposeWe previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic the ability of BRCA1 to inhibit ERα activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound, the hydrochloride salt… read more here.
Keywords: nsc35446 hcl; antiestrogen resistant; breast cancer; ikkb promoter ... See more keywords