Suppression of NSCLC A549 tumor growth by a mtDNA mutation-targeting pyrrole-imidazole polyamide-TPP and a senolytic drug.
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DOI: 10.1111/cas.15290
Abstract: Certain somatic mutations in mitochondrial DNA (mtDNA) were associated with tumor progression and frequently found in a homoplasmic state. We recently reported that pyrrole-imidazole polyamide conjugated with the mitochondria-delivering moiety triphenylphosphonium (PIP-TPP) targeting a mtDNA… read more here.
Keywords: tumor; nsclc a549; mtdna mutation; pyrrole imidazole ... See more keywords