Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100778
Abstract: Although the farnesoid X receptor (FXR) has been regarded as a promising drug target for metabolic diseases as well as anti‐inflammatory, antitumor and antiviral actions, the antagonism by FXR ligands are still underrepresented in current… read more here.
Keywords: metastasis; cell proliferation; nsclc cell; modification fxr ... See more keywords
Dynamic EGFR interactomes reveal differential association of signaling modules with wildtype and Exon19-del EGFR in NSCLC cell lines.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2022.104555
Abstract: Protein-protein interaction networks (PPIs) govern the majority of biological processes, but how oncogenic mutations impact these interactions and their functions at a network scale is poorly understood. Mutations of epidermal growth factor receptor (EGFR) in… read more here.
Keywords: nsclc cell; egfr; cell; cell lines ... See more keywords
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117054119
Abstract: Significance The G protein–coupled bile acid receptor (GPBAR) is the native bile acid receptor and therapeutic target for treating metabolic diseases. However, specific bile acids are suspected to promote cancer progression. We showed that different… read more here.
Keywords: cell; cell growth; nsclc cell; gpbar ... See more keywords
LncRNA WT1-AS/miR-494-3p Regulates Cell Proliferation, Apoptosis, Migration and Invasion via PTEN/PI3K/AKT Signaling Pathway in Non-Small Cell Lung Cancer
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DOI: 10.2147/ott.s278233
Abstract: Background Non-small cell lung cancer (NSCLC) is one of the most common malignancies with the highest morbidity and mortality worldwide. Long non-coding RNAs (lncRNAs) are recently recognized as noteworthy regulators of different tumors, counting NSCLC.… read more here.
Keywords: cell proliferation; mir 494; nsclc cell; wt1 mir ... See more keywords
GPX4 Plays a Crucial Role in Fuzheng Kang’ai Decoction-Induced Non-Small Cell Lung Cancer Cell Ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.851680
Abstract: Background: Fuzheng Kang’ai decoction (FZKA) has been widely used to treat Non-Small Cell Lung Cancer (NSCLC) patients in China for decades, showing definitively curative effects in clinic. Recently, we found that FZKA could induce NSCLC… read more here.
Keywords: cell; nsclc cell; cell ferroptosis; fzka ... See more keywords
N,Nʹ-Diarylurea Derivatives (CTPPU) Inhibited NSCLC Cell Growth and Induced Cell Cycle Arrest through Akt/GSK-3β/c-Myc Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021357
Abstract: Lung cancer is one of the most common malignancies worldwide. Non-small-cell lung cancer (NSCLC) accounts for more than 80% of lung cancers, shows chemotherapy resistance, metastasis, and relapse. The phosphatidylinositol-3 kinase (PI3K)/Akt pathway has been… read more here.
Keywords: cell; nsclc cell; cell cycle; ctppu ... See more keywords