Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation
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DOI: 10.1002/advs.202501335
Abstract: Immunotherapy efficacy in NSCLC is significantly reduced upon liver metastasis due to profound alterations in the tumor microenvironment, characterized by the absence of cyclic mechanical stretch and increased extracellular matrix (ECM) stiffness. However, the mechanisms… read more here.
Keywords: nsclc liver; immunotherapy; metastasis; liver metastasis ... See more keywords
Effect of personalized approach to therapy in non-small cell lung cancer (NSCLC) with liver metastasis with immunotherapy on outcomes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e21504
Abstract: e21504Background: Patients with NSCLC with liver metastasis tend to have significantly reduced overall survival (OS) compared to NSCLC with metastasis to other sites. We aimed looking at the patien... read more here.
Keywords: personalized approach; effect personalized; approach therapy; nsclc liver ... See more keywords