USP15 Drives NSCLC Progression and Chemoresistance, Potentially via Regulation of the U2‐Type Spliceosomal Complex
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DOI: 10.1002/cam4.71055
Abstract: Non‐small cell lung cancer (NSCLC) is an aggressive and lethal malignancy with the highest cancer‐related mortality rate. More than 50% of patients are diagnosed at advanced stages, often accompanied by chemoresistance and poor prognosis. Deubiquitinases… read more here.
Keywords: drives nsclc; nsclc progression; progression chemoresistance; usp15 drives ... See more keywords
ALKBH5‐Mediated m6A Modification of XBP1 Facilitates NSCLC Progression Through the IL‐6–JAK–STAT3 Pathway
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DOI: 10.1002/mc.23826
Abstract: The X‐box‐binding protein 1 (XBP1) is an important transcription factor during endoplasmic reticulum stress response, which was reported as an oncogene in non‐small cell lung cancer (NSCLC) tumorigenesis and development. However, the regulatory mechanism of… read more here.
Keywords: modification xbp1; m6a modification; nsclc progression; xbp1 ... See more keywords
TFAP2A drives non-small cell lung cancer (NSCLC) progression and resistance to targeted therapy by facilitating the ESR2-mediated MAPK pathway
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DOI: 10.1038/s41420-024-02251-5
Abstract: Cancer is among the leading causes of death related diseases worldwide, and lung cancer has the highest mortality rate in the world. Transcription factors (TFs) constitute a class of structurally and functionally intricate proteins. Aberrant… read more here.
Keywords: lung cancer; cancer; tfap2a; nsclc progression ... See more keywords
Circ_0026134 promotes NSCLC progression by the miR‐3619‐5p/CHAF1B axis
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DOI: 10.1111/1759-7714.14301
Abstract: Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Circular RNAs (circRNAs) have been implicated in the pathogenesis of NSCLC. In this study, we explored the molecular determinants underlying the oncogenic… read more here.
Keywords: nsclc progression; promotes nsclc; mir 3619; circ 0026134 ... See more keywords
ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis
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DOI: 10.1155/2022/7527996
Abstract: Purpose Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been reported to be overexpressed in non-small-cell lung cancer (NSCLC) and to correlate with malignant proliferation. However, the mechanism of high MTHFD2 expression in NSCLC has not been clarified.… read more here.
Keywords: nsclc progression; atf4 myc; expression; myc ... See more keywords
USP21-EGFR-Lyn axis drives NSCLC progression and therapeutic potential of USP21 inhibition
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DOI: 10.1186/s40364-025-00806-x
Abstract: Non-small cell lung cancer (NSCLC) is a highly aggressive malignancy frequently driven by oncogenic mutations in the epidermal growth factor receptor (EGFR). Although EGFR-tyrosine kinase inhibitors (EGFR-TKIs) have shown clinical efficacy, challenges such as limited… read more here.
Keywords: egfr; usp21 egfr; therapeutic potential; nsclc progression ... See more keywords
circGFRA1 Enhances NSCLC Progression by Sponging miR-188-3p
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DOI: 10.2147/ott.s230795
Abstract: Background Lung cancer continues to be one of the most dangerous tumors around the world. It is an urgency to explore the molecular mechanism of non-small cell lung cancer (NSCLC) progression for developing novel therapeutic… read more here.
Keywords: nsclc progression; mir 188; circgfra1 mir;
Pseudogene KRT17P3 Promotes NSCLC Progression Through Mir-338-3p/USP7/C-Myc
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DOI: 10.21873/anticanres.17367
Abstract: Background/Aim: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality, yet its underlying molecular mechanisms remain poorly understood. Previous research has identified the pseudogene KRT17P3 as a key player in NSCLC chemoresistance,… read more here.
Keywords: mir 338; usp7 myc; krt17p3; nsclc progression ... See more keywords
Decreased TSPAN14 Expression Contributes to NSCLC Progression
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DOI: 10.3390/life12091291
Abstract: Tspan14 is a transmembrane protein of the tetraspanin (Tspan) protein family. Different members of the Tspan family can promote or suppress tumor progression. The exact role of Tspan14 in tumor cells is unknown. Earlier, mutational… read more here.
Keywords: nsclc progression; expression; tspan14; tumor ... See more keywords