NSD1 Mutations and Pediatric High-Grade Gliomas: A Comparative Genomic Study in Primary and Recurrent Tumors
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DOI: 10.3390/diagnostics13010078
Abstract: Pediatric high-grade gliomas represent a heterogeneous group of tumors with a wide variety of molecular features. We performed whole exome sequencing and methylation profiling on matched primary and recurrent tumors from four pediatric patients with… read more here.
Keywords: high grade; grade gliomas; nsd1 mutations; primary recurrent ... See more keywords
NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint
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DOI: 10.3390/life12070988
Abstract: An increasing amount of evidence indicates the critical role of the NSD1 gene in Sotos syndrome (SoS), a rare genetic disease, and in tumors. Molecular mechanisms affected by NSD1 mutations are largely uncharacterized. In order… read more here.
Keywords: noncoding rnas; expression; nsd1 mutations; change benjamini ... See more keywords