Abstract 4837: NSD2 modulates immune surveillance in multiple myeloma
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DOI: 10.1158/1538-7445.am2025-4837
Abstract: The histone methyltransferase NSD2 is overexpressed in 15% of multiple myeloma (MM) patients due to the translocation (4;14). NSD2 overexpression disrupts chromatin methylation promoting oncogenic gene expression. Despite advancements in MM treatments, the t(4;14) translocation… read more here.
Keywords: expression; nsd2; immune surveillance; multiple myeloma ... See more keywords
NSD2 Regulates Pro-Metastatic Gene PTP4A3 through Chromatin Remodeling in Multiple Myeloma
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DOI: 10.1182/blood-2020-134766
Abstract: Nuclear receptor-binding SET domain 2 (NSD2) is the primary oncogenic driver and represent a good druggable target due to its universal overexpression in t(4;14) MM. However, given the challenges in the development of small molecule… read more here.
Keywords: ptp4a3; myeloma; chromatin remodeling; nsd2 ... See more keywords