An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia
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DOI: 10.1038/s41388-018-0474-y
Abstract: NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL), and cells harboring this mutation… read more here.
Keywords: nsd2 histone; histone methyltransferase; lymphocytic leukemia; acute lymphocytic ... See more keywords