Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor
Sign Up to like & getrecommendations! Published in 2017 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9753-8
Abstract: NSD3 is a histone H3 methyltransferase that plays an important role in chromatin biology. A construct containing the methyltransferase domain encompassing residues Q1049-K1299 of human NSD3 was obtained and biochemical activity was demonstrated using histone… read more here.
Keywords: backbone resonance; resonance assignments; methyltransferase; nsd3 ... See more keywords
Abstract 6986: Discovery of trihydroxyflavone from botanical sources targeting the epigenomic driver NSD3 in lung squamous cell carcinoma
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DOI: 10.1158/1538-7445.am2025-6986
Abstract: Lung squamous cell carcinoma (LSCC) represents a highly aggressive subtype of non-small cell lung cancer, accounting for approximately 30% of all lung cancer cases. Despite its significant prevalence, effective targeted therapies for LSCC remain elusive,… read more here.
Keywords: cell; squamous cell; nsd3; cell carcinoma ... See more keywords
Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
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DOI: 10.3390/life11080726
Abstract: NSD3 is one of six H3K36-specific lysine methyltransferases in metazoans, and the methylation of H3K36 is associated with active transcription. NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases… read more here.
Keywords: function nsd3; nsd3; nsd3 protein; structure activity ... See more keywords