CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC
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DOI: 10.1038/leu.2017.346
Abstract: CRISPR/Cas9 edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC read more here.
Keywords: edited nsg; pdx models; crispr cas9; mice pdx ... See more keywords
NSG mice as hosts for oncological precision medicine
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0298-6
Abstract: Patient-derived xenograft (PDX) models have been rediscovered as meaningful research tool. By using severely immunodeficient mice, high-engraftment rates can be theoretically achieved, permitting clinical stratification strategies. Apart from engraftment efficacy, tolerability towards certain cytostatic drugs… read more here.
Keywords: medicine; nsg mice; precision medicine; pdx models ... See more keywords
Human delta like 1-expressing human mesenchymal stromal cells promote human T cell development and antigen-specific response in humanized NOD/SCID/IL-2R[Formula: see text]null (NSG) mice.
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DOI: 10.1038/s41598-021-90110-z
Abstract: Human delta-like 1 (hDlk1) is known to be able to regulate cell fate decisions during hematopoiesis. Mesenchymal stromal cells (MSCs) are known to exhibit potent immunomodulatory roles in a variety of diseases. Herein, we investigated… read more here.
Keywords: humanized nsg; response; nsg mice; cell ... See more keywords
Exploring dose–response variability and relative severity assessment in STZ-induced diabetes male NSG mice
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DOI: 10.1038/s41598-024-67490-z
Abstract: NSG mice are among the most immunodeficient mouse model being used in various scientific branches. In diabetelogical research diabetic NSG mice are an important asset as a xenotransplantation model for human pancreatic islets or pluripotent… read more here.
Keywords: mice; relative severity; nsg mice; male nsg ... See more keywords
Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction
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DOI: 10.1158/1535-7163.mct-18-0977
Abstract: To provide a better understanding of the pharmacokinetics–pharmacodynamics relationships of antibody-based drugs, we analyzed several chimeric and humanized monoclonal antibodies or antibody–drug conjugates (ADC) for PK and efficacy among four strains of mice. Notably, antibodies… read more here.
Keywords: nsg mice; antibody drug; drug; efficacy ... See more keywords
Abstract 1070: Evaluation of human NK cell responses to PDX tumors in humanized NOD-scid IL2rgnull(NSG) mice expressing human IL15
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1070
Abstract: Human innate immunity plays a critical role in tumor surveillance and in immunoregulation within the tumor microenvironment. Natural killer (NK) cells are innate lymphoid cells that have opposing roles in the tumor microenvironment, including NK… read more here.
Keywords: il15 mice; nsg mice; mice; nsg il15 ... See more keywords
Comparison of biological features between severely immuno-deficient NOD/Shi-scid Il2rgnull and NOD/LtSz-scid Il2rgnull mice
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DOI: 10.1538/expanim.19-0024
Abstract: Biological background data up to 11 weeks of age and tumorigenic susceptibility to xenotransplantation with HeLa cells were compared between severely immuno-deficient NOG and NSG mice. The body weight was lower in NOG mice than… read more here.
Keywords: nod; mice; severely immuno; nsg mice ... See more keywords
The Epidemiology of Invasive, Multipleantibiotic- resistant Klebsiella pneumoniae Infection in a Breeding Colony of Immunocompromised NSG Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Comparative medicine"
DOI: 10.30802/aalas-cm-21-000088
Abstract: Klebsiella pneumoniae (Kp) is a gram-negative opportunistic pathogen that causes severe pneumonia, pyelonephritis, and sepsis in immunocompromised hosts. During a 4-mo interval, several NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) breeders and pups in our facilities were diagnosed with Kp… read more here.
Keywords: nsg mice; klebsiella pneumoniae; epidemiology; mice ... See more keywords
A Clinical Scoring Systems for the Evaluation of Corynebacterium bovis -associated Disease in NSG Mice.
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DOI: 10.30802/aalas-cm-22-000098
Abstract: Clinical signs of Corynebacterium bovis infections are well-known in athymic nude mice. However, C. bovis can also infect and cause clinical signs in many hirsute, immunocompromised mouse strains such as NSG (NOD. Cg-Prkdcscid Il2rgtm1Wgl/SzJ). Typically,… read more here.
Keywords: bovis; nsg mice; clinical scoring; corynebacterium bovis ... See more keywords
In-Vitro and In-Vivo Establishment and Characterization of Bioluminescent Orthotopic Chemotherapy-Resistant Human Osteosarcoma Models in NSG Mice
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DOI: 10.3390/cancers11070997
Abstract: Osteosarcoma, the most common bone malignancy with a peak incidence at adolescence, had no survival improvement since decades. Persistent problems are chemo-resistance and metastatic spread. We developed in-vitro osteosarcoma models resistant to chemotherapy and in-vivo… read more here.
Keywords: osteosarcoma models; bioluminescent orthotopic; drug; resistance ... See more keywords
Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection
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DOI: 10.3390/v15020365
Abstract: Mice reconstituted with human immune systems are instrumental in the investigation of HIV-1 pathogenesis and therapeutics. Natural killer (NK) cells have long been recognized as a key mediator of innate anti-HIV responses. However, established humanized… read more here.
Keywords: nsg mice; cell; cell responses; robust ... See more keywords