Identification of novel mutations in the methyltransferase complex (Nsp10-Nsp16) of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100833
Abstract: A recent outburst of the pandemic caused by a member of the coronaviridae family identified as SARS-CoV-2. The highly contagious nature of the virus allows it to spread rapidly worldwide and caused severe healthcare and… read more here.
Keywords: sars cov; nsp10 nsp16; methyltransferase complex; identification novel ... See more keywords
Optimizing peptide inhibitors of SARS-Cov-2 nsp10/nsp16 methyltransferase predicted through molecular simulation and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2022.100886
Abstract: Coronaviruses, including the recent pandemic strain SARS-Cov-2, use a multifunctional 2′-O-methyltransferase (2′-O-MTase) to restrict the host defense mechanism and to methylate RNA. The nonstructural protein 16 2′-O-MTase (nsp16) becomes active when nonstructural protein 10 (nsp10)… read more here.
Keywords: sars cov; methyltransferase; optimizing peptide; peptide inhibitors ... See more keywords
Abrogating the nsp10–nsp16 switching mechanisms in SARS-CoV-2 by phytochemicals from Withania somnifera: a molecular dynamics study
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Simulation"
DOI: 10.1080/08927022.2021.1974432
Abstract: ABSTRACT The search for therapeutic small molecules and vaccines for Covid-19 treatment is an urgent but evolving topic. The virus has claimed over 3,782,490 lives (as of 12 June 2021), with the figure expected to… read more here.
Keywords: withania somnifera; sars cov; nsp10 nsp16; molecular dynamics ... See more keywords
Identification and Inhibition of the Druggable Allosteric Site of SARS-CoV-2 NSP10/NSP16 Methyltransferase through Computational Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165241
Abstract: Since its emergence in early 2019, the respiratory infectious virus, SARS-CoV-2, has ravaged the health of millions of people globally and has affected almost every sphere of life. Many efforts are being made to combat… read more here.
Keywords: allosteric site; site sars; nsp10 nsp16; methyltransferase ... See more keywords