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   Articles with "nt2 cells" as a keyword



Complementation of dopaminergic signaling by Pitx3–GDNF synergy induces dopamine secretion by multipotent Ntera2 cells

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recommendations! Published in 2019 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.29109

Abstract: Human teratocarcinoma cell line Ntera2 (NT2) expresses dopamine signals and has shown its safe profile for clinical applications. Attempts to restore complete dopaminergic (DAergic) phenotype enabling these cells to secrete dopamine have not been fully… read more here.

Keywords: complementation dopaminergic; gdnf; nt2 cells; pitx3 gdnf ... See more keywords

CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-52675-3

Abstract: The human neuron-specific gene, GPM6B (Glycoprotein membrane 6B), is considered a key gene in neural cell functionality. This gene contains an exceptionally long and strictly monomorphic short tandem repeat (STR) of 9-repeats, (GA)9. STRs in… read more here.

Keywords: repeat; deletion; nt2 cells; deletion repeat ... See more keywords

Histone modifications on the promoters of human OCT4 and NANOG genes at the onset of neural differentiation of NT2/D1 cells

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recommendations! Published in 2017 at "Biochemistry (Moscow)"

DOI: 10.1134/s0006297917060086

Abstract: Transcription factors OCT4 and NANOG are main constituents of a functional network that controls proliferation and pluripotency maintenance of stem cells as well as early lineage decisions. We investigated expression profiles of OCT4 and NANOG… read more here.

Keywords: neural differentiation; histone modifications; nanog genes; differentiation ... See more keywords

Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells

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recommendations! Published in 2025 at "Life Science Alliance"

DOI: 10.26508/lsa.202402946

Abstract: PRMT6, through its methyltransferase activity, contributes to alternative splicing in both pluripotent and neuronally differentiating NT2/D1 cells, affecting primarily cassette exons. Protein arginine methyltransferase 6 (PRMT6) is a well-characterized epigenetic regulator that methylates histone H3… read more here.

Keywords: splicing pluripotent; prmt6 dependent; alternative splicing; nt2 cells ... See more keywords