Abstract 1740: Generation of a best-in-class AR-NTD inhibitor targeting a unique binding pocket identified by computational modeling
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1740
Abstract: Current prostate cancer (PC) therapies for both mCRPC and nmCRPC patients are limited to targeting the ligand-binding domain (LBD). But due to the emergence of LBD lacking variants, and mutations in the LBD of androgen… read more here.
Keywords: ntd inhibitor; ntd; structure; inhibitor ... See more keywords
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158177
Abstract: Mutations in the spike protein of SARS-CoV-2 can lead to evasion from neutralizing antibodies and affect the efficacy of passive and active immunization strategies. Immunization of mice harboring an entire set of human immunoglobulin variable… read more here.
Keywords: escape mutants; ntd; rbd; cluster ... See more keywords