Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate
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DOI: 10.1124/dmd.122.000855
Abstract: Tenofovir (TFV; prescribed as TFV disoproxil fumarate and TFV alafenamide prodrugs) is currently used for HIV prevention and treatment. TFV must be phosphorylated twice into TFV-diphosphate (TFV-DP) to become pharmacologically active. Previously, we reported heterogeneity… read more here.
Keywords: dephosphorylation; ntpdase; tfv; colorectal tissue ... See more keywords
Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses
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DOI: 10.1128/jvi.01404-18
Abstract: The genome sequences of the koala and wombat gammaherpesviruses show that the viruses form a distinct branch, indicative of a novel genus within the Gammaherpesvirinae. Their genomes contain several new ORFs, including ORFs encoding a… read more here.
Keywords: viral ntpdase; host; koala wombat; ntpdase ... See more keywords