NTRK fusions in lung cancer: From biology to therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Lung cancer"
DOI: 10.1016/j.lungcan.2021.09.005
Abstract: Fusions involving TRK protein tyrosine kinases are oncogenic drivers in a variety of tumors in children and adults, with a prevalence of ∼0.2% in non-small cell lung cancer. Diagnosis can be challenging due to structural… read more here.
Keywords: ntrk fusions; trk; biology; lung cancer ... See more keywords
Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST)
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0623-z
Abstract: Mesenchymal tumors driven by NTRK fusions are clinically and morphologically heterogeneous. With an increasing number of clinicopathological entities being associated with NTRK fusions, the diagnostic and predictive value of the identification of NTRK fusions is… read more here.
Keywords: gastrointestinal tract; tract ntrk; tract; ntrk fusions ... See more keywords
NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab016
Abstract: Diffuse midline gliomas (DMGs) are incurable pediatric tumors with extraordinarily limited treatment options. Decades of clinical trials combining conventional chemotherapies with radiation therapy have failed to improve these outcomes, demonstrating the need to identify and… read more here.
Keywords: ntrk fusions; midline gliomas; gliomas; diffuse midline ... See more keywords
NTRK gene fusions are detected in both secretory and non‐secretory breast cancers
Sign Up to like & getrecommendations! Published in 2022 at "Pathology International"
DOI: 10.1111/pin.13204
Abstract: NTRK fusions represent a new biomarker‐defined population that can be treated with TRK inhibitors. Although rare, NTRK fusions are detected across a wide range of solid tumors. Previous reports suggest that NTRK fusions are limited… read more here.
Keywords: non secretory; ntrk fusions; breast; secretory subtype ... See more keywords
NTRK Fusions Detection in Paediatric Sarcomas to Expand the Morphological Spectrum and Clinical Relevance of Selected Entities
Sign Up to like & getrecommendations! Published in 2022 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2022.1610237
Abstract: Undifferentiated round cell sarcomas (URCS) of soft tissue and bone and tumours of uncertain differentiation (TUD) are commonly ascribed to a subset of neoplasms with low frequency of NTRK gene fusions. However, more recently NTRK-rearranged… read more here.
Keywords: detection paediatric; sarcomas; positive cases; paediatric sarcomas ... See more keywords
NTRK Fusions in 1113 Solid Tumors in a Single Institution
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12061450
Abstract: Simple Summary Recently, there has been increasing interest in identifying NTRK fusions in various tumors, as they are therapeutically targetable driver mutations. In tumor types with low-frequency NTRK fusions, recent recommendations on NTRK testing recommend… read more here.
Keywords: trk expression; ntrk fusions; pan trk; 1113 solid ... See more keywords
TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by NTRK Fusions
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315366
Abstract: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease… read more here.
Keywords: merkel cell; cell carcinoma; ntrk fusions; expression ... See more keywords
Current and emerging biomarkers in metastatic colorectal cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Current oncology"
DOI: 10.3747/co.26.5719
Abstract: Background The incorporation of novel biomarkers into therapy selection for patients with metastatic colorectal cancer (mcrc) has significantly improved outcomes. Optimal treatment planning now takes into account diverse characteristics of patients and their tumours to… read more here.
Keywords: metastatic colorectal; current emerging; colorectal cancer; ntrk fusions ... See more keywords