NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors
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DOI: 10.1038/s42003-020-01508-w
Abstract: Tyrosine kinase domains dynamically fluctuate between two main structural forms that are referred to as type I (DFG-in) or type II (DFG-out) conformations. Comprehensive data comparing type I and type II inhibitors are currently lacking… read more here.
Keywords: type inhibitors; sensitivity; type; type type ... See more keywords