Abstract C122: NUC-7738, a novel ProTide modification of 3’-deoxyadenosine, activates AMPK and kills renal cancer cellsin vitro
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c122
Abstract: Background: Cordycepin or 3′-deoxyadenosine inhibits the growth of cancer cells by several possible mechanisms. The ProTide NUC-7738, a phosphoramidate transformation of cordycepin, is designed to overcome cancer resistance mechanisms through direct release of 3’-deoxyadenosine monophosphate… read more here.
Keywords: deoxyadenosine; pampk; renal cancer; cancer ... See more keywords
Abstract 277: NUC-7738 promotes alternative polyadenylation site usage and reduces glutaminase GAC isoform
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-277
Abstract: Background: Metabolic dysregulation, a hallmark of cancer, allows tumor cells to sustain high rates of growth and proliferation in unfavorable conditions, including hypoxia. Many cancers, including clear cell renal cell carcinoma (ccRCC), demonstrate the Warburg… read more here.
Keywords: alternative polyadenylation; nuc 7738; polyadenylation; gac isoform ... See more keywords
NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells
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DOI: 10.1371/journal.pone.0278209
Abstract: Acute myeloid leukemia (AML) stem cells are required for the initiation and maintenance of the disease. Activation of the Wnt/β-catenin pathway is required for the survival and development of AML leukaemia stem cells (LSCs) and… read more here.
Keywords: aml; catenin signalling; aml cells; signalling resulting ... See more keywords