Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner
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DOI: 10.1038/s41598-017-04005-z
Abstract: Symplekin is a multifunctional protein that localizes to both tight junctions and the nucleus in polarized epithelial cells, with confirmed roles in mRNA maturation, transcriptional modulation and tight-junction assembly. However, the mechanisms governing its subcellular… read more here.
Keywords: symplekin; accumulation; nuclear symplekin; proliferation dedifferentiation ... See more keywords
Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos
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DOI: 10.1126/sciadv.aat6224
Abstract: MET-2/SETDB1 and interactors LIN-65/ATF7IP and ARLE-14/ARL14EP initiate heterochromatin formation during embryogenesis. Heterochromatin formation during early embryogenesis is timed precisely, but how this process is regulated remains elusive. We report the discovery of a histone methyltransferase… read more here.
Keywords: histone methyltransferase; nuclear accumulation; heterochromatin formation; formation ... See more keywords
Abstract 2592: Helicobacter pylori-induced FGFR4 mediates nuclear accumulation of NRF2 in gastric tumorigenesis
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DOI: 10.1158/1538-7445.am2023-2592
Abstract: Background: Fibroblast growth factor receptor 4 (FGFR4) is a member of the transmembrane tyrosine kinase receptor family and has been linked to a variety of malignancies. NRF2 (Nuclear factor-erythroid 2-related factor) is a cytoprotective factor… read more here.
Keywords: nuclear accumulation; fgfr4; accumulation nrf2; accumulation ... See more keywords
4-Hydroxy-2-nonenal causes nuclear accumulation of p62 by inhibiting Xpo1 and promoting the proteolytic pathway in the nucleus
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DOI: 10.1371/journal.pone.0316558
Abstract: p62, an adapter protein involved in selective autophagy, is mainly found in the cytoplasm under normal conditions. Because p62 has nuclear localization signal (NLS) and a nuclear export signal, it has been suggested that p62… read more here.
Keywords: nuclear accumulation; p62; nonenal causes; inhibiting xpo1 ... See more keywords
Nuclear Accumulation of HSP70 in Mouse Skeletal Muscles in Response to Heat Stress, Aging, and Unloading With or Without Reloading
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DOI: 10.3389/fgene.2018.00617
Abstract: The purpose of this study was to investigate the nuclear accumulation of heat shock protein 70 (HSP70), a molecular chaperonin in mouse skeletal muscle in response to aging, heat stress, and hindlimb unloading with or… read more here.
Keywords: accumulation; hsp70; accumulation hsp70; response ... See more keywords