Nuclear actin in cancer biology.
Sign Up to like & getrecommendations! Published in 2020 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2020.04.001
Abstract: The presence of actin in the nucleus has been a matter of debate for many years. In recent years many important roles of actin in the nucleus (transcriptional regulation, chromatin remodeling, DNA repair, cell division,… read more here.
Keywords: actin; actin cancer; biology; nuclear actin ... See more keywords
Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26839-y
Abstract: Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as… read more here.
Keywords: nuclear capture; invasion; capture endosomes; nuclear actin ... See more keywords
SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Reports"
DOI: 10.1038/s44319-024-00274-8
Abstract: The nucleoskeleton is essential for nuclear architecture as well as genome integrity and gene expression. In addition to lamins, titin or spectrins, dynamic actin filament polymerization has emerged as a potential intranuclear structural element but… read more here.
Keywords: rna polymerase; sun2; rna; polymerization ... See more keywords
Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae574
Abstract: Abstract Nuclear actin-based movements support DNA double-strand break (DSB) repair. However, molecular determinants that promote filamentous actin (F-actin) formation on the damaged chromatin remain undefined. Here we describe the DYRK1A kinase as a nuclear activity… read more here.
Keywords: actin assembly; dsb; nuclear actin; actin ... See more keywords
Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay6515
Abstract: Nuclear actin promotes the formation of inducible transcription factory, as a general mechanism of the rapid response to stimuli. Gene expression in response to stimuli underlies many fundamental processes. However, how transcription is regulated under… read more here.
Keywords: response; actin; inducible transcription; rna polymerase ... See more keywords
Baculovirus AC102 Is a Nucleocapsid Protein That Is Crucial for Nuclear Actin Polymerization and Nucleocapsid Morphogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00111-18
Abstract: ABSTRACT The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the type species of alphabaculoviruses, is an enveloped DNA virus that infects lepidopteran insects and is commonly known as a vector for protein expression and cell transduction.… read more here.
Keywords: protein; actin; nucleocapsid morphogenesis; infection ... See more keywords
SEPTIN6 mutations in pediatric myelodysplastic syndrome disrupt nuclear actin organization
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-4999
Abstract: Septins are a family of evolutionarily conserved GTP-binding proteins that play critical roles in cytoskeletal organization, cytokinesis, and intracellular trafficking forming cytoplasmic filaments interacting with each other, Rho GTPases and other cytoskeleton proteins. We previously… read more here.
Keywords: organization; septin6; mds; nuclear actin ... See more keywords
Nuclear F-actin and Lamin A antagonistically modulate nuclear shape
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259692
Abstract: ABSTRACT Nuclear shape influences cell migration, gene expression and cell cycle progression, and is altered in disease states like laminopathies and cancer. What factors and forces determine nuclear shape? We find that nuclei assembled in… read more here.
Keywords: actin lamin; nuclear actin; nuclear shape; shape ... See more keywords
The prophase oocyte nucleus is a homeostatic G-actin buffer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259807
Abstract: Formation of healthy mammalian eggs from oocytes requires specialised F-actin structures. F-actin disruption produces aneuploid eggs, which are a leading cause of human embryo deaths, genetic disorders, and infertility. We found that oocytes contain prominent… read more here.
Keywords: actin; nuclear actin; nucleus homeostatic; oocyte nucleus ... See more keywords
Investigation of the Potential Mechanisms Underlying Nuclear F-Actin Organization in Ovarian Cancer Cells by High-Throughput Screening in Combination With Deep Learning
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.869531
Abstract: Increasing evidence supports the notion that filamentous actin (F-actin) and globular actin exist in the nuclei of somatic cells, and are involved in chromatin remodeling, gene transcription regulation and DNA damage repair. However, the underlying… read more here.
Keywords: ovarian cancer; nuclear actin; combination deep; screening combination ... See more keywords
New Insights into Cellular Functions of Nuclear Actin
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10040304
Abstract: Simple Summary It is well known that actin forms a cytoplasmic network of microfilaments, the part of the cytoskeleton, in the cytoplasm of eukaryotic cells. The presence of nuclear actin was elusive for a very… read more here.
Keywords: actin; actin plays; role; new insights ... See more keywords