Formaldehyde-Mediated Snapshot of Nuclear Architecture.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0664-3_10
Abstract: Genome architecture and function are strictly related to nuclear structures, which contact chromatin at specific regions, regulating its compaction and three-dimensional higher-order structure, therefore contributing to specialized gene expression programs. Recently, growing evidence uncovers a… read more here.
Keywords: snapshot nuclear; formaldehyde mediated; nuclear architecture; biology ... See more keywords
Sites of chromosomal instability in the context of nuclear architecture and function
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03698-2
Abstract: Chromosomal fragile sites are described as areas within the tightly packed mitotic chromatin that appear as breaks or gaps mostly tracing back to a loosened structure and not a real nicked break within the DNA… read more here.
Keywords: fragile sites; nuclear architecture; chromosomal instability; instability context ... See more keywords
Simple FISH-based evaluation of spermatic nuclear architecture shows an abnormal chromosomal organization in balanced chromosomal rearrangement carriers
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-020-01736-3
Abstract: Introduction Interphasic DNA has a constant three-dimensional conformation, which is particularly striking for spermatic DNA, with distinct chromosomal territories and a constant chromosomal conformation. We hypothesized that this organization is fragile, and that an excess… read more here.
Keywords: nuclear architecture; spermatic nuclear; rearrangement carriers; organization ... See more keywords
Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2022.01.024
Abstract: SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe damage in a variety of organs. Thus, deciphering the non-cell autonomous effects of SARS-CoV-2 infection is imperative for understanding… read more here.
Keywords: sars cov; cell autonomous; non cell; disruption ... See more keywords
DNA damage-induced inflammation and nuclear architecture
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2016.09.008
Abstract: Nuclear architecture and the chromatin state affect most-if not all- DNA-dependent transactions, including the ability of cells to sense DNA lesions and restore damaged DNA back to its native form. Recent evidence points to functional… read more here.
Keywords: nuclear architecture; dna damage; damage induced; dna ... See more keywords
Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.02.003
Abstract: Heart failure is associated with hypertrophying of cardiomyocytes and changes in transcriptional activity. Studies from rapidly dividing cells in culture have suggested that transcription may be compartmentalized into factories within the nucleus, but this phenomenon… read more here.
Keywords: transcription; rna polymerase; nuclear architecture; transcription factories ... See more keywords
Single-cell nuclear architecture across cell types in the mouse brain
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abj1966
Abstract: Description Nuclear organization in the brain The brain consists of different cell types, neurons and glial cells, that have different nuclear architecture. Takei et al. used multiplexed imaging tools to examine the spatial arrangement of… read more here.
Keywords: cell types; nuclear architecture; cell; mouse brain ... See more keywords
Investigating cell cycle-dependent gene expression in the context of nuclear architecture at single-allele resolution
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.246330
Abstract: ABSTRACT Nuclear architecture is the organization of the genome within a cell nucleus with respect to different nuclear landmarks such as the nuclear lamina, nuclear matrix or nucleoli. Recently, nuclear architecture has emerged as a… read more here.
Keywords: nuclear architecture; gene; cell; gene expression ... See more keywords