Inhibition of Ferroptosis Attenuates Glutamate Excitotoxicity and Nuclear Autophagy in a CLP Septic Mouse Model
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DOI: 10.1097/shk.0000000000001893
Abstract: ABSTRACT Sepsis-associated encephalopathy (SAE) often manifests in severe diffuse cerebral dysfunction due to an aberrant systemic immune response to infection. The underlying pathophysiology of SAE is not entirely understood but is likely a multifactorial process… read more here.
Keywords: nuclear autophagy; inhibition ferroptosis; sae; glutamate excitotoxicity ... See more keywords
The Absence of Gasdermin D Reduces Nuclear Autophagy in a Cecal Ligation and Puncture-Induced Sepsis-Associated Encephalopathy Mouse Model
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DOI: 10.3390/brainsci13030478
Abstract: Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, which is a life-threatening condition resulting from a dysregulated host response to infection. Pyroptosis, a pro-inflammatory mode of lytic cell death mediated by GSDMD (Gasdermin D),… read more here.
Keywords: sepsis; nuclear autophagy; associated encephalopathy; sepsis associated ... See more keywords