MED26‐containing Mediator may orchestrate multiple transcription processes through organization of nuclear bodies
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DOI: 10.1002/bies.202200178
Abstract: Mediator is a coregulatory complex that plays essential roles in multiple processes of transcription regulation. One of the human Mediator subunits, MED26, has a role in recruitment of the super elongation complex (SEC) to polyadenylated… read more here.
Keywords: transcription; organization nuclear; med26 containing; mediator ... See more keywords
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.06.019
Abstract: Despite the prominent role of TDP-43 in neurodegeneration, its physiological and pathological functions are not fully understood. Here, we report an unexpected role of TDP-43 in the formation of dynamic, reversible, liquid droplet-like nuclear bodies… read more here.
Keywords: phase separation; liquid phase; stress; lncrna neat1 ... See more keywords
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45038
Abstract: The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes… read more here.
Keywords: pml nuclear; ddit4; expression; mtor ... See more keywords
PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad152
Abstract: We have uncovered a novel role for the promyelocytic leukemia (PML) gene and novel PML-like DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE-1 (L1) retrotransposition in jawed vertebrates. Although the… read more here.
Keywords: pml; pml like; gar pml; pml pml ... See more keywords
The SUMO Conjugation Complex Self-Assembles into Nuclear Bodies Independent of SIZ1 and COP11[OPEN]
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DOI: 10.1104/pp.18.00910
Abstract: SUMO conjugation activity causes the formation of SUMO nuclear bodies, which strongly overlap with COP1-containing nuclear bodies due to a VP motif in the E3 ligase SIZ1 that acts as bridge protein. Attachment of the… read more here.
Keywords: sumo conjugation; cop1; conjugation activity; nuclear bodies ... See more keywords
Nuclear Bodies Built on Architectural Long Noncoding RNAs: Unifying Principles of Their Construction and Function
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DOI: 10.14348/molcells.2017.0263
Abstract: Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis, storage, and sequestration of specific RNAs, proteins, or ribonucleoprotein complexes. Recent studies reveal that a… read more here.
Keywords: architectural long; long noncoding; construction function; noncoding rnas ... See more keywords
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes
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DOI: 10.3389/fcell.2021.715868
Abstract: Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes. Here we analyze the relationship between two key transcription factors: CBX4, a… read more here.
Keywords: target genes; cbx4 stability; nuclear bodies; stability ... See more keywords
The Role of Promyelocytic Leukemia Nuclear Bodies During HPV Infection
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00035
Abstract: Promyelocytic leukemia (PML) nuclear bodies (NBs) are highly dynamic subnuclear structures. Their name giving major component, PML protein, is essential for their formation. PML is present in many different isoforms due to differential splicing, which… read more here.
Keywords: promyelocytic leukemia; nuclear bodies; pml; pml nbs ... See more keywords
Identification of Key Proteins from the Alternative Lengthening of Telomeres-Associated Promyelocytic Leukemia Nuclear Bodies Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11020185
Abstract: Simple Summary The alternative lengthening of telomeres is a telomere maintenance mechanism used by some cancer types to elongate their telomeres without the aid of telomerase. This mechanism contributes to the proliferation and immortality of… read more here.
Keywords: cancer; nuclear bodies; lengthening telomeres; promyelocytic leukemia ... See more keywords
Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases
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DOI: 10.3390/ncrna6010006
Abstract: Nuclear bodies are membraneless, phase-separated compartments that concentrate specific proteins and RNAs in the nucleus. They are believed to serve as sites for the modification, sequestration, and storage of specific factors, and to act as… read more here.
Keywords: repeat enriched; nuclear bodies; tandem repeat; short tandem ... See more keywords
Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System
Sign Up to like & getrecommendations! Published in 2017 at "Viruses"
DOI: 10.3390/v9100308
Abstract: Gammaherpesviruses like Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. In particular, viral tegument proteins that share… read more here.
Keywords: proteasome system; tegument proteins; nuclear bodies; ubiquitin proteasome ... See more keywords