N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.04.017
Abstract: N6-Methyladenosine (m6A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m6A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is the essential m6A… read more here.
Keywords: phase; methyladenosine; differentiation; m6a ... See more keywords
RING tetramerization is required for nuclear body biogenesis and PML sumoylation
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DOI: 10.1038/s41467-018-03498-0
Abstract: ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the… read more here.
Keywords: nuclear body; pml; pml sumoylation; ring tetramerization ... See more keywords
Insight into nuclear body formation of phytochromes through stochastic modelling and experiment.
Sign Up to like & getrecommendations! Published in 2018 at "Physical biology"
DOI: 10.1088/1478-3975/aac193
Abstract: Spatial relocalization of proteins is crucial for the correct functioning of living cells. An interesting example of spatial ordering is the light-induced clustering of plant photoreceptor proteins. Upon irradiation by white or red light, the… read more here.
Keywords: body formation; insight nuclear; formation phytochromes; nuclear body ... See more keywords
Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes
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DOI: 10.1242/bio.059130
Abstract: ABSTRACT Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core. Although multiple membrane-less… read more here.
Keywords: nuclear body; pml nbs; pml; promyelocytic leukemia ... See more keywords