Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
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DOI: 10.1016/j.yjmcc.2018.10.011
Abstract: In cardiac myocytes Calmodulin (CaM) bound to the ryanodine receptor (RyR2) constitutes a large pool of total myocyte CaM, but the CaM-RyR2 affinity is reduced in pathological conditions. Knock-in mice expressing RyR2 unable to bind… read more here.
Keywords: cam; nuclear cam; ryr2; pathological cardiac ... See more keywords