Blockade of Nuclear β‐Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis
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DOI: 10.1002/advs.202202528
Abstract: Colorectal cancer (CRC) is one of the most common malignant tumors in the world, with high prevalence and low 5‐year survival. Most of the CRC patients show excessive activation of the Wnt/β‐catenin pathway which is… read more here.
Keywords: nu2058; catenin; ranbp3; crc ... See more keywords
Regulation of β-catenin by IGFBP2 and its cytoplasmic actions in glioma
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DOI: 10.1007/s11060-020-03596-4
Abstract: IGFBP2 is one of the highly expressed genes in glioblastoma (GBM). It has both IGF dependent and independent activities. IGF independent actions are mediated by the activation of integrin signalling through its RGD motif present… read more here.
Keywords: nuclear catenin; regulation catenin; catenin; cytoplasmic catenin ... See more keywords
Activation of nuclear β-catenin/c-Myc axis promotes oxidative stress injury in streptozotocin-induced diabetic cardiomyopathy.
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DOI: 10.1016/j.bbrc.2017.10.027
Abstract: Myocardial oxidative stress injury plays a crucial role in the pathogenesis of diabetic cardiomyopathy (DCM). Wnt/β-catenin signaling has been reported to involve in various heart diseases. However, the underlying mechanism associated with β-catenin in DCM… read more here.
Keywords: nuclear catenin; catenin myc; catenin; oxidative stress ... See more keywords
Tumor-Intrinsic Nuclear β-Catenin Associates with an Immune Ignorance Phenotype and a Poorer Prognosis in Head and Neck Squamous Cell Carcinomas
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DOI: 10.3390/ijms231911559
Abstract: Activation of WNT/β-catenin signaling has been associated with a non-T-cell-inflamed tumor microenvironment (TME) in several cancers. The aim of this work was to investigate the relationship between β-catenin signaling and TME inflammation in head and… read more here.
Keywords: cell; head neck; nuclear catenin; catenin ... See more keywords