Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.10.057
Abstract: Phase transitions involving biomolecular liquids are a fundamental mechanism underlying intracellular organization. In the cell nucleus, liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is implicated in assembly of the nucleolus, as well as transcriptional… read more here.
Keywords: liquid nuclear; condensates mechanically; sense restructure; restructure genome ... See more keywords
Cold-induced Arabidopsis FRIGIDA nuclear condensates for FLC repression.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04062-5
Abstract: Plants use seasonal temperature cues to time the transition to reproduction. In Arabidopsis thaliana, winter cold epigenetically silences the floral repressor locus FLOWERING LOCUS C (FLC) through POLYCOMB REPRESSIVE COMPLEX 2 (PRC2)1. This vernalization process… read more here.
Keywords: temperature; flc repression; nuclear condensates; repression ... See more keywords
Drug modulation by nuclear condensates
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abc5318
Abstract: Concentration of antineoplastic agents into spatial compartments influences activity Many mysteries remain about the eukaryotic nucleus. In the past decade, much has been discovered anew about the three-dimensional (3D) organization of the nucleus and the… read more here.
Keywords: drug; drug modulation; modulation nuclear; nuclear condensates ... See more keywords
Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells
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DOI: 10.1186/s12915-021-01178-y
Abstract: Background The Mediator complex is an evolutionarily conserved multi-subunit protein complex that plays major roles in transcriptional activation and is essential for cell growth, proliferation, and differentiation. Recent studies revealed that some Mediator subunits formed… read more here.
Keywords: med15; nuclear condensates; complex subunit; subunit med15 ... See more keywords
Nuclear Condensates: New Targets to Combat Parasite Immune Evasion?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.942200
Abstract: Antigenic variation is a successful strategy employed by numerous pathogens to evade the host immune system. It describes the frequent exchange of antigens, which prevents detection and elimination by the host immune system. Strikingly, pathogens… read more here.
Keywords: nuclear condensates; antigenic variation; transcription; variation ... See more keywords