Dose-Dependent Nuclear Delivery and Transcriptional Repression with a Cell-Penetrant MeCP2
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01226
Abstract: Methyl-CpG-binding-protein 2 (MeCP2) is a nuclear protein expressed in all cell types, especially neurons1. Mutations in the MECP2 gene cause Rett syndrome (RTT), an incurable neurological disorder that disproportionately affects young girls2. Strategies to restore… read more here.
Keywords: cell; cell penetrant; nuclear delivery; mecp2 ... See more keywords
An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr02118h
Abstract: Nucleic acid therapy is attracting great attention in diverse clinical translations because of its therapeutic advantages. As a renowned oligonucleotide therapeutical candidate in the clinical stage, AS1411 has shown outstanding tumor suppressing effects; however, its… read more here.
Keywords: pdc; cell; nuclear delivery; nucleic acid ... See more keywords
PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007590
Abstract: Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing… read more here.
Keywords: protein; transport; nuclear delivery; hpv ... See more keywords