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   Articles with "nuclear delivery" as a keyword



Dose-Dependent Nuclear Delivery and Transcriptional Repression with a Cell-Penetrant MeCP2

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recommendations! Published in 2022 at "ACS Central Science"

DOI: 10.1021/acscentsci.2c01226

Abstract: Methyl-CpG-binding-protein 2 (MeCP2) is a nuclear protein expressed in all cell types, especially neurons1. Mutations in the MECP2 gene cause Rett syndrome (RTT), an incurable neurological disorder that disproportionately affects young girls2. Strategies to restore… read more here.

Keywords: cell; cell penetrant; nuclear delivery; mecp2 ... See more keywords

An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.

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recommendations! Published in 2022 at "Nanoscale"

DOI: 10.1039/d2nr02118h

Abstract: Nucleic acid therapy is attracting great attention in diverse clinical translations because of its therapeutic advantages. As a renowned oligonucleotide therapeutical candidate in the clinical stage, AS1411 has shown outstanding tumor suppressing effects; however, its… read more here.

Keywords: pdc; cell; nuclear delivery; nucleic acid ... See more keywords

Explaining the Proliferation of Nuclear Delivery Vehicles

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recommendations! Published in 2025 at "Security Studies"

DOI: 10.1080/09636412.2025.2541654

Abstract: Abstract How and why do nuclear delivery vehicles proliferate? This article identifies a permissive environment in the nonproliferation regime shaped by three drivers for proliferation: First, the multipurpose or dual-use nature of the technology to… read more here.

Keywords: explaining proliferation; nonproliferation regime; delivery; delivery vehicles ... See more keywords

PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery

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recommendations! Published in 2019 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1007590

Abstract: Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing… read more here.

Keywords: protein; transport; nuclear delivery; hpv ... See more keywords