Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
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DOI: 10.1101/2022.06.05.494868
Abstract: Cytoplasmic dynein plays crucial roles in the intracellular transport of organelles and other cargoes. Central to dynein function is the intrinsically disordered N-terminal domain of dynein intermediate chain (IC), which binds the three dimeric dynein… read more here.
Keywords: intermediate chain; distribution protein; nuclear distribution; autoinhibition ... See more keywords
Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)‐binding protein 1 in Huntington's disease
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DOI: 10.1111/neup.12600
Abstract: Huntington's disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the huntingtin protein. Immunohistochemical studies using the 1C2 antibody for polyglutamine expansion have detected characteristic intranuclear inclusions (INIs) in affected… read more here.
Keywords: huntington disease; disease; poly binding; binding protein ... See more keywords