The amino acids of Autographa californica multiple nucleopolyhedrovirus P48 critical for the association with Ac93 are important for the nuclear egress of nucleocapsids and efficient formation of intranuclear microvesicles.
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DOI: 10.1016/j.virusres.2021.198644
Abstract: Autographa californica multiple nucleopolyhedrovirus (AcMNPV) undergoes a biphasic life cycle with the production of two physically and functionally distinct virions: budded virions (BVs) and occlusion-derived virions (ODVs). Nuclear egress of nucleocapsids and intranuclear microvesicle formation… read more here.
Keywords: nucleocapsids efficient; formation; p48; egress nucleocapsids ... See more keywords
Differentiating the Roles of UL16, UL21, and Us3 in the Nuclear Egress of Herpes Simplex Virus Capsids
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DOI: 10.1128/jvi.00738-20
Abstract: The membrane deformation activity of the herpesvirus nuclear egress complex (NEC) allows capsids to transit through both nuclear membranes into the cytoplasm. NEC activity must be precisely controlled during viral infection, and yet our knowledge… read more here.
Keywords: egress; pul21; nuclear egress; virus ... See more keywords
Lysine 242 within Helix 10 of the Pseudorabies Virus Nuclear Egress Complex pUL31 Component Is Critical for Primary Envelopment of Nucleocapsids
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DOI: 10.1128/jvi.01182-17
Abstract: ABSTRACT Newly assembled herpesvirus nucleocapsids are translocated from the nucleus to the cytosol by a vesicle-mediated process engaging the nuclear membranes. This transport is governed by the conserved nuclear egress complex (NEC), consisting of the… read more here.
Keywords: pul31; nuclear membrane; egress complex; nuclear egress ... See more keywords
Autographa californica Multiple Nucleopolyhedrovirus ac75 Is Required for the Nuclear Egress of Nucleocapsids and Intranuclear Microvesicle Formation
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DOI: 10.1128/jvi.01509-17
Abstract: ABSTRACT Autographa californica multiple nucleopolyhedrovirus (AcMNPV) orf75 (ac75) is a highly conserved gene of unknown function. In this study, we constructed an ac75 knockout AcMNPV bacmid and investigated the role of ac75 in the baculovirus… read more here.
Keywords: formation; nucleocapsids intranuclear; intranuclear microvesicle; egress nucleocapsids ... See more keywords
A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress
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DOI: 10.1128/jvi.01849-17
Abstract: ABSTRACT Herpesviruses replicate and package their genomes into capsids in replication compartments within the nuclear interior. Capsids then move to the inner nuclear membrane for envelopment and release into the cytoplasm in a process called… read more here.
Keywords: nuclear egress; human cytomegalovirus; myosin; microscopy ... See more keywords
Roles of the Different Isoforms of the Pseudorabies Virus Protein Kinase pUS3 in Nuclear Egress
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DOI: 10.1128/jvi.02029-19
Abstract: A plethora of substrates and functions have been assigned to the alphaherpesviral pUS3 kinase, including a role in nuclear egress. In PrV, two different pUS3 isoforms are expressed, which differ in size, abundance, and intracellular… read more here.
Keywords: role; kinase; pus3; nuclear egress ... See more keywords
pUL21 regulation of pUs3 kinase activity influences the nature of nuclear envelope deformation by the HSV-2 nuclear egress complex
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DOI: 10.1371/journal.ppat.1009679
Abstract: It is well established that the herpesvirus nuclear egress complex (NEC) has an intrinsic ability to deform membranes. During viral infection, the membrane-deformation activity of the NEC must be precisely regulated to ensure efficient nuclear… read more here.
Keywords: nuclear envelope; pus3; hsv nec; nuclear egress ... See more keywords
G2/M checkpoint regulation and apoptosis facilitate the nuclear egress of parvoviral capsids
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DOI: 10.3389/fcell.2022.1070599
Abstract: The nuclear export factor CRM1-mediated pathway is known to be important for the nuclear egress of progeny parvovirus capsids in the host cells with virus-mediated cell cycle arrest at G2/M. However, it is still unclear… read more here.
Keywords: checkpoint; infection; nuclear egress; checkpoint regulation ... See more keywords
Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97
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DOI: 10.3390/v10010035
Abstract: The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. The latter has been studied… read more here.
Keywords: nuclear capsids; egress; capsid; nuclear egress ... See more keywords
The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors
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DOI: 10.3390/v14051021
Abstract: The nucleo-cytoplasmic capsid egress of herpesviruses is a unique regulated process that ensures the efficiency of viral replication and release. For human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the… read more here.
Keywords: core; antiviral kinase; associated host; nuclear egress ... See more keywords