Mutant NPM1: Nuclear export and the mechanism of leukemogenesis
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26862
Abstract: NPM1 -mutated acute myeloid leukemia (AML) represents the most frequent genetic subtype of AML, accounting for about 30% to 35% of newly diagnosed cases in adults. 1 Because of its distinctive clinico-pathological and molecular features,… read more here.
Keywords: mutant npm1; npm1 mutated; npm1 nuclear; nuclear export ... See more keywords
Protein kinase B/AKT mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28353
Abstract: Insulin‐like growth factor 1 (IGF‐1) mediates the generation of reactive oxygen species (ROS) and the activation of growth promoting signaling pathways. Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone… read more here.
Keywords: hdac5 phosphorylation; nuclear export; igf; activation ... See more keywords
Engineering chromosome region maintenance 1 fragments that bind to nuclear export signals
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3724
Abstract: Chromosome region maintenance 1 (CRM1) exports nuclear export signal (NES) containing cargos from nucleus to cytoplasm and plays critical roles in cancer and viral infections. Biochemical and biophysical studies on this protein were often obstructed… read more here.
Keywords: nuclear export; region maintenance; chromosome region;
Selinexor, selective inhibitor of nuclear export: Unselective bullet for blood cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Blood reviews"
DOI: 10.1016/j.blre.2020.100758
Abstract: Exportin 1 (XPO1), also known as chromosome maintenance 1 protein (CRM1), is the main transporter for hundreds of proteins like tumor suppressors, growth regulatory factors, oncoprotein mRNAs and others. Its upregulation leads to the inactivation… read more here.
Keywords: export; selective inhibitor; nuclear export; selinexor selective ... See more keywords
The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.04.061
Abstract: Summary Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-coding products. Many transcripts are short lived due to their nuclear degradation by the ribonucleolytic RNA exosome. Here, we show that abolished nuclear exosome function causes… read more here.
Keywords: export; export activity; rna exosome; nuclear export ... See more keywords
A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.07.103
Abstract: Summary Genomes are promiscuously transcribed, necessitating mechanisms that facilitate the sorting of RNA for function or destruction. The polyA (pA) tail is one such distinguishing feature, which in the Saccharomyces cerevisiae nucleus is bound by… read more here.
Keywords: export; export block; nuclear export; rna ... See more keywords
China's nuclear export drive: Trojan Horse or Marshall Plan?
Sign Up to like & getrecommendations! Published in 2017 at "Energy Policy"
DOI: 10.1016/j.enpol.2016.09.038
Abstract: China's civil nuclear industry expanded strongly from 2008 onwards and nearly half of reactor construction starts worldwide since then are accounted for by the Chinese home market. Increasingly China is turning its attention to the… read more here.
Keywords: export; export drive; nuclear export; china ... See more keywords
Russia's Nuclear Export Programme
Sign Up to like & getrecommendations! Published in 2018 at "Energy Policy"
DOI: 10.1016/j.enpol.2018.06.036
Abstract: Abstract Since 2009, after a largely dormant period since the Chernobyl disaster, Russia, through Rosatom, has come to dominate the world reactor export market with a new design it claims achieves equivalent safety standards to… read more here.
Keywords: export; russia nuclear; nuclear export; russia ... See more keywords
Effect of urea concentration on instant refolding of Nuclear Export Protein (NEP) from Influenza-A virus H1N1: A solution NMR based investigation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.10.146
Abstract: Nuclear-export-protein (NEP) plays multiple-functions during influenza virus replication-cycle and shows unique pattern of conserved residues, which altogether make NEP a potential target for developing novel anti-influenza drugs. However, the mechanistic structural biology of NEP has… read more here.
Keywords: solution nmr; nuclear export; protein nep; solution ... See more keywords
Proteomics identify nuclear export as a targetable pathway in neuroblastoma: Comment on “XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IκB”
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101150
Abstract: Neuroblastoma (NBL) is an embryonal malignancy of childhood with poor outcomes for patient with high-risk disease. Multimodal treatment approaches have improved outcomes but at the cost of significant toxicity, and there is no durable therapeutic… read more here.
Keywords: export; nuclear export; inhibition; identify nuclear ... See more keywords
Prediction of ligands to universally conserved binding sites of the influenza a virus nuclear export protein.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.08.013
Abstract: The nuclear export protein (NEP) of the influenza A virus exports viral ribonucleoproteins to the host cell cytoplasm following nuclear transcription. In this work conservation analysis of 3000 protein sequences and molecular modelling of full-length… read more here.
Keywords: nuclear export; binding sites; export; export protein ... See more keywords