Mutant NPM1: Nuclear export and the mechanism of leukemogenesis
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26862
Abstract: NPM1 -mutated acute myeloid leukemia (AML) represents the most frequent genetic subtype of AML, accounting for about 30% to 35% of newly diagnosed cases in adults. 1 Because of its distinctive clinico-pathological and molecular features,… read more here.
Keywords: mutant npm1; npm1 mutated; npm1 nuclear; nuclear export ... See more keywords
Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202500195
Abstract: Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export… read more here.
Keywords: nuclear export; crm1 inhibitors; chromenone derivatives; glioblastoma ... See more keywords
Protein kinase B/AKT mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28353
Abstract: Insulin‐like growth factor 1 (IGF‐1) mediates the generation of reactive oxygen species (ROS) and the activation of growth promoting signaling pathways. Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone… read more here.
Keywords: hdac5 phosphorylation; nuclear export; igf; activation ... See more keywords
Engineering chromosome region maintenance 1 fragments that bind to nuclear export signals
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3724
Abstract: Chromosome region maintenance 1 (CRM1) exports nuclear export signal (NES) containing cargos from nucleus to cytoplasm and plays critical roles in cancer and viral infections. Biochemical and biophysical studies on this protein were often obstructed… read more here.
Keywords: nuclear export; region maintenance; chromosome region;
Prognostic and functional role of the nuclear export receptor 1 (XPO1) in gastrointestinal cancers: a potential novel target?
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology Reports"
DOI: 10.1007/s11033-024-10169-5
Abstract: In the last decades the survival of metastatic gastrointestinal (GI) cancer patients could have been significantly extended due to the introduction of targeted- and immunotherapy. However, only the minority of patients will experience long-lasting survival.… read more here.
Keywords: nuclear export; cancer; role; cancer patients ... See more keywords
Selinexor, selective inhibitor of nuclear export: Unselective bullet for blood cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Blood reviews"
DOI: 10.1016/j.blre.2020.100758
Abstract: Exportin 1 (XPO1), also known as chromosome maintenance 1 protein (CRM1), is the main transporter for hundreds of proteins like tumor suppressors, growth regulatory factors, oncoprotein mRNAs and others. Its upregulation leads to the inactivation… read more here.
Keywords: export; selective inhibitor; nuclear export; selinexor selective ... See more keywords
The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.04.061
Abstract: Summary Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-coding products. Many transcripts are short lived due to their nuclear degradation by the ribonucleolytic RNA exosome. Here, we show that abolished nuclear exosome function causes… read more here.
Keywords: export; export activity; rna exosome; nuclear export ... See more keywords
A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.07.103
Abstract: Summary Genomes are promiscuously transcribed, necessitating mechanisms that facilitate the sorting of RNA for function or destruction. The polyA (pA) tail is one such distinguishing feature, which in the Saccharomyces cerevisiae nucleus is bound by… read more here.
Keywords: export; export block; nuclear export; rna ... See more keywords
China's nuclear export drive: Trojan Horse or Marshall Plan?
Sign Up to like & getrecommendations! Published in 2017 at "Energy Policy"
DOI: 10.1016/j.enpol.2016.09.038
Abstract: China's civil nuclear industry expanded strongly from 2008 onwards and nearly half of reactor construction starts worldwide since then are accounted for by the Chinese home market. Increasingly China is turning its attention to the… read more here.
Keywords: export; export drive; nuclear export; china ... See more keywords
Russia's Nuclear Export Programme
Sign Up to like & getrecommendations! Published in 2018 at "Energy Policy"
DOI: 10.1016/j.enpol.2018.06.036
Abstract: Abstract Since 2009, after a largely dormant period since the Chernobyl disaster, Russia, through Rosatom, has come to dominate the world reactor export market with a new design it claims achieves equivalent safety standards to… read more here.
Keywords: export; russia nuclear; nuclear export; russia ... See more keywords
Effect of urea concentration on instant refolding of Nuclear Export Protein (NEP) from Influenza-A virus H1N1: A solution NMR based investigation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.10.146
Abstract: Nuclear-export-protein (NEP) plays multiple-functions during influenza virus replication-cycle and shows unique pattern of conserved residues, which altogether make NEP a potential target for developing novel anti-influenza drugs. However, the mechanistic structural biology of NEP has… read more here.
Keywords: solution nmr; nuclear export; protein nep; solution ... See more keywords