CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model
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DOI: 10.1126/scitranslmed.aaz2415
Abstract: CDK12 inhibition reduces mutant transcripts and nuclear foci in DM1 cells and produces splicing correction and phenotypic benefit in a mouse model. Muscling in on myotonic dystrophy Myotonic dystrophy type 1 (DM1) is a genetic… read more here.
Keywords: dm1; nuclear foci; inhibition; myotonic dystrophy ... See more keywords