The non‐canonical nuclear functions of key players of the PI3K‐AKT‐MTOR pathway
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DOI: 10.1002/jcp.30782
Abstract: The PI3K‐AKT‐MTOR signal transduction pathway is one of the essential signalling cascades within the cell due to its involvement in many vital functions. The pathway initiates with the recruitment of phosphatidylinositol‐3 kinases (PI3Ks) onto the… read more here.
Keywords: pi3k akt; nuclear functions; akt mtor; non canonical ... See more keywords
Nuclear Phosphoinositides: Their Regulation and Roles in Nuclear Functions
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DOI: 10.3390/ijms20122991
Abstract: Polyphosphoinositides (PPIns) are a family of seven lipid messengers that regulate a vast array of signalling pathways to control cell proliferation, migration, survival and differentiation. PPIns are differentially present in various sub-cellular compartments and, through… read more here.
Keywords: nuclear phosphoinositides; nuclear functions; phosphoinositides regulation; roles nuclear ... See more keywords
New Insights on the Nuclear Functions and Targeting of FAK in Cancer
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DOI: 10.3390/ijms23041998
Abstract: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed and activated in both adult and pediatric cancers, where it plays important roles in the regulation of pathogenesis and progression of the malignant phenotype. FAK… read more here.
Keywords: cancer; insights nuclear; nuclear functions; functions targeting ... See more keywords