Chemogenomic Active Learning's Domain of Applicability on Small, Sparse qHTS Matrices: A Study Using Cytochrome P450 and Nuclear Hormone Receptor Families
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700677
Abstract: Computational models for predicting the activity of small molecules against targets are now routinely developed and used in academia and industry, partially due to public bioactivity databases. While models based on bigger datasets are the… read more here.
Keywords: active learning; hormone receptor; nuclear hormone; cytochrome p450 ... See more keywords
Nuclear hormone receptors promote gut and glia detoxifying enzyme induction and protect C. elegans from the mold P. brevicompactum
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110166
Abstract: SUMMARY Animals encounter microorganisms in their habitats, adapting physiology and behavior accordingly. The nematode Caenorhabditis elegans is found in microbe-rich environments; however, its responses to fungi are not extensively studied. Here, we describe interactions of… read more here.
Keywords: brevicompactum; induction; hormone receptors; nuclear hormone ... See more keywords
Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8
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DOI: 10.1016/j.isci.2020.101068
Abstract: Summary Cholesterol is an essential nutrient for the function of diverse biological processes and for steroid biosynthesis across metazoans. However, the role of cholesterol in immune function remains understudied. Using the nematode Caenorhabditis elegans, which… read more here.
Keywords: hormone receptor; cholesterol; nuclear hormone; innate immunity ... See more keywords
Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH
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DOI: 10.1016/j.molmet.2020.101153
Abstract: Background Non-alcoholic steatohepatitis (NASH) is a spectrum of histological liver pathologies ranging from hepatocyte fat accumulation, hepatocellular ballooning, lobular inflammation, and pericellular fibrosis. Based on early investigations, it was discovered that visceral fat accumulation, hepatic… read more here.
Keywords: hormone; peptide; hormone peptide; nuclear hormone ... See more keywords
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14750
Abstract: The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on… read more here.
Keywords: concise guide; guide pharmacology; pharmacology 2019; pharmacology ... See more keywords
The function of nuclear hormone receptor 4A signaling in the human reproductive system: A review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15264
Abstract: This review aims to summarize the research focused upon the functions of nuclear hormone receptor 4A (NR4A) in the human reproductive system. The research questions addressed are to decipher what role the NR4A subfamily plays… read more here.
Keywords: human reproductive; review; hormone receptor; reproductive system ... See more keywords
Differential expression of nuclear hormone receptors by dendritic cell subsets in human vaginal mucosa and skin
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1063343
Abstract: Nuclear hormone receptors (NHRs) expressed by dendritic cells (DCs), the major immune inducers and regulators, could play important roles in host immunity. Assessment of NHRs expressed by DCs in the vaginal mucosa (VM), in comparison… read more here.
Keywords: cell; expression; hormone receptors; nuclear hormone ... See more keywords