Light‐Dependent Cytoplasmic Recruitment Enhances the Dynamic Range of a Nuclear Import Photoswitch
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700681
Abstract: Cellular signal transduction is often regulated at multiple steps to achieve more complex logic or precise control of a pathway. For instance, some signaling mechanisms couple allosteric activation with localization to achieve high signal to… read more here.
Keywords: import; import photoswitch; dynamic range; nuclear import ... See more keywords
Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28591
Abstract: Proteins UL31 and UL34 encoded by alphaherpesvirus are critical for viral primary envelopment and nuclear egress. We report here that pseudorabies virus (PRV), a useful model for research on herpesvirus pathogenesis, uses N‐myc downstream regulated… read more here.
Keywords: ndrg1 expression; nuclear import; ul31 ul34; hsc70 ... See more keywords
Hormone-Inducible Transport Reporter Assay to Study Nuclear Import Defects in Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2337-4_5
Abstract: In the recent years, defective nuclear import has emerged as an important pathomechanism of neurodegenerative diseases, particularly in amyotrophic lateral sclerosis (ALS). Here, specific nuclear RNA binding proteins (RBPs) mislocalize and aggregate in the cytoplasm… read more here.
Keywords: import; hormone inducible; nuclear import; inducible transport ... See more keywords
Importin KPNA2 confers HIV-1 pre-integration complex nuclear import by interacting with the capsid protein.
Sign Up to like & getrecommendations! Published in 2022 at "Antiviral research"
DOI: 10.1016/j.antiviral.2022.105289
Abstract: For human immunodeficiency virus 1 (HIV-1) to infect non-dividing cells, pre-integration complex (PIC) must be transported into the nucleus within the replication cycle. We previously reported that the karyopherin β1 (KPNB1)-nucleoporin Pom121 pathway, related to… read more here.
Keywords: import; pic nuclear; nuclear import; kpna2 ... See more keywords
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.03.003
Abstract: Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. Physical mechanisms that control condensate formation/dissolution are poorly understood. The RNA-binding protein fused in sarcoma… read more here.
Keywords: phase separation; fus; receptor inhibits; import receptor ... See more keywords
Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108201
Abstract: SUMMARY HIV-1 reverse transcription (RT) occurs before or during uncoating, but the cellular compartment where RT and uncoating occurs is unknown. Using imaging and biochemical assays to track HIV-1 capsids in the nucleus during infection,… read more here.
Keywords: import hiv; hiv; reverse transcription; nuclear import ... See more keywords
ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin β1 for non-classical nuclear import.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.08.029
Abstract: The latency-associated nuclear antigens (LANA) of KSHV and macaque RFHVMn, members of the RV1 rhadinovirus lineage, are closely related with conservation of complex nuclear localization signals (NLS) containing bipartite KR-rich motifs and RG-rich domains, which… read more here.
Keywords: lana homologs; non classical; import; rrv mnerv2 ... See more keywords
Synthetic Monopartite Peptide That Enables the Nuclear Import of Genes Delivered by the Neurotensin-Polyplex Vector.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00755
Abstract: Neurotensin (NTS)-polyplex is a multicomponent nonviral vector that enables gene delivery via internalization of the neurotensin type 1 receptor (NTSR1) to dopaminergic neurons and cancer cells. An approach to improving its therapeutic safety is replacing… read more here.
Keywords: vector; peptide; monopartite peptide; synthetic monopartite ... See more keywords
Active Nuclear Import of Mammalian Cell-Expressible DNA Origami
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12733
Abstract: DNA origami enables the creation of complex 3D shapes from genetic material. Future uses could include the delivery of genetic instructions to cells, but nuclear import remains a major barrier to gene delivery due to… read more here.
Keywords: dna; nuclear import; dna origami; active nuclear ... See more keywords
Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53909-5
Abstract: Inactivation of the protein complex ‘mechanistic target of rapamycin complex 1’ (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transducer and activator… read more here.
Keywords: apoptosis; target rapamycin; pkc; rapamycin ... See more keywords
AGR2-dependent nuclear import of RNA polymerase II constitutes a specific target of pancreatic ductal adenocarcinoma in the context of wild-type p53.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.07.030
Abstract: BACKGROUND AND AIM Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells' neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). Agr2 (anterior gradient 2), a known inhibitor of p53, is detected at early… read more here.
Keywords: rnapii; wild type; type p53; nuclear import ... See more keywords