Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29522
Abstract: Nonalcoholic fatty liver disease (NAFLD) is becoming the major chronic liver disease in many countries. Its pathogenesis is multifactorial, but twin and familial studies indicate significant heritability, which is not fully explained by currently known… read more here.
Keywords: nuclear lamina; nonalcoholic fatty; liver disease; truncated lap2 ... See more keywords
A user-interactive algorithm quantifying nuclear pore complex distribution within the nuclear lamina network in single molecular localization microscopic image.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.09.006
Abstract: For decades, components of the mammalian nuclear envelope (NE), such as the nuclear lamina and nuclear pore complexes (NPCs), have been largely resistant to quantitative cell biological analysis using conventional fluorescence microscopy. This is in… read more here.
Keywords: nuclear lamina; within nuclear; microscopy; nuclear pore ... See more keywords
Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09185-y
Abstract: How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood. Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope. This increases… read more here.
Keywords: required proper; nuclear lamina; lamina integrity; integrity required ... See more keywords
Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Microbiology"
DOI: 10.1038/s41564-018-0285-5
Abstract: Tripartite motif (TRIM) proteins mediate antiviral host defences by either directly targeting viral components or modulating innate immune responses. Here we identify a mechanism of antiviral restriction in which a TRIM E3 ligase controls viral… read more here.
Keywords: nuclear lamina; lamina integrity; herpesvirus infection; trim43 ... See more keywords
PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina
Sign Up to like & getrecommendations! Published in 2022 at "Nucleus"
DOI: 10.1080/19491034.2023.2165602
Abstract: The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery. However, the mechanisms by… read more here.
Keywords: heterochromatin; h3k9me3 modified; prr14; nuclear lamina ... See more keywords
Differential contributions of nuclear lamina association and genome compartmentalization to gene regulation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleus"
DOI: 10.1080/19491034.2023.2197693
Abstract: Interactions of chromatin with the nuclear lamina play a significant role in properly organizing the genome in 3D space and in regulating gene expression. Genome wide studies have inferred the global association between the lamina,… read more here.
Keywords: lamin association; nuclear lamina; gene expression; gene ... See more keywords
High quality mapping of chromatin at or near the nuclear lamina from small numbers of cells reveals cell cycle and developmental changes of chromatin at the nuclear periphery
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac762
Abstract: Abstract The chromatin associated with the nuclear lamina (NL) is referred to as lamina-associated domains (LADs). Here, we present an adaptation of the tyramide-signal amplification sequencing (TSA-seq) protocol, which we call chromatin pull down-based TSA-seq… read more here.
Keywords: seq; ctsa seq; nuclear lamina; chromatin near ... See more keywords
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13531
Abstract: Experimental and clinical therapies in the field of Alzheimer's disease (AD) have focused on elimination of extracellular amyloid beta aggregates or prevention of cytoplasmic neuronal fibrillary tangles formation, yet these approaches have been generally ineffective.… read more here.
Keywords: nuclear lamina; role cathepsin; induction nuclear; cathepsin ... See more keywords
The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.240416
Abstract: ABSTRACT A large fraction of epigenetically silent heterochromatin is anchored to the nuclear periphery via ‘tethering proteins’ that function to bridge heterochromatin and the nuclear membrane or nuclear lamina. We previously identified a human tethering… read more here.
Keywords: heterochromatin; nuclear lamina; modular domains; prr14 ... See more keywords
The nuclear lamina binds the EBV genome during latency and regulates viral gene expression
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010400
Abstract: The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals. In latently infected cells,… read more here.
Keywords: ebv genome; latency; gene expression; nuclear lamina ... See more keywords
Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.913458
Abstract: Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical… read more here.
Keywords: nuclear lamina; lamina interactions; biology model; chromatin nuclear ... See more keywords