NAD+ Metabolism Reprogramming Drives SIRT1‐Dependent Deacetylation Inducing PD‐L1 Nuclear Localization in Cervical Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202412109
Abstract: Cervical cancer (CC) is a major health threat to women, with immunotherapies targeting the programmed death receptor 1/programmed death ligand 1(PD‐1/PD‐L1) axis showing promise but encountering resistance in a significant patient population. This resistance has… read more here.
Keywords: nad metabolism; cervical cancer; nuclear localization; deacetylation ... See more keywords
Characterization of nuclear localization signal in Ostrinia furnacalis Masculinizer protein.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21768
Abstract: Bombyx mori Masculinizer protein (BmMasc) is essential for both masculinization and dosage compensation in B. mori. We previously identified a bipartite nuclear localization signal (NLS) of BmMasc and two essential residues (lysine at 274 [K274]… read more here.
Keywords: nuclear localization; masculinizer protein; ostrinia furnacalis; localization ... See more keywords
Comment on “Nuclear localization of LDL receptor-related protein 1B in mammary gland carcinogenesis”
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01773-1
Abstract: To the editor: We read with great interest the article by Asano and colleagues [1]. The study illuminated that the nuclear-localized LRP1B intracellular domain promoted breast cancer progression with poor prognosis, which possibly through the… read more here.
Keywords: nuclear localization; microarray; analysis; comment nuclear ... See more keywords
Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling
Sign Up to like & getrecommendations! Published in 2020 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-020-0807-1
Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Patients with HF exhibit a loss of junctophilin-2 (JPH2), a structural protein critical in forming junctional membrane complexes in which excitation–contraction takes place.… read more here.
Keywords: nuclear localization; cleavage; jph2 ctp; jph2 ... See more keywords
Trypanosoma cruzi Importin α: ability to bind to a functional classical nuclear localization signal of the bipartite type.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology research"
DOI: 10.1007/s00436-020-06885-z
Abstract: Importin α, a transport factor in the classical pathway of nuclear transport of proteins in eukaryotes, has not been experimentally studied in trypanosomatids. A chimeric fluorescent version of this protein (TcImportin α-EGFP) expressed in transfected… read more here.
Keywords: nuclear localization; importin; ability; localization ... See more keywords
Characterization of the Eimeria tenella rhoptry protein with a nuclear localization sequence (EtROP30)
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology Research"
DOI: 10.1007/s00436-022-07499-3
Abstract: Rhoptry proteins (ROPs), secreted by specific rhoptry organelles of apicomplexan parasites, are determinants of parasite pathogenesis and sources of vaccine candidates. Twenty-eight ROPs of Eimeria tenella have been predicted by genomic approaches, and in the… read more here.
Keywords: rhoptry; tenella; sequence; protein ... See more keywords
Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of virology"
DOI: 10.1007/s00705-021-05026-w
Abstract: Although dengue virus (DENV) replication occurs in the cytoplasm, the nucleus plays an essential role during infection. Both the capsid protein (C) and non-structural protein 5 (NS5) are translocated into the infected cell nucleus to… read more here.
Keywords: protein; dengue virus; nuclear localization; non structural ... See more keywords
Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9711-z
Abstract: G protein-coupled receptors (GPCRs) comprise the main signal-transmitting components in the cell membrane. Over the past several years, biochemical and structural analyses have immensely enhanced our knowledge of GPCR involvement in health and disease states.… read more here.
Keywords: nuclear localization; protein coupled; catenin nuclear; localization transcriptional ... See more keywords
Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.107
Abstract: GLI1 is a key downstream transcription effector of the Hedgehog (Hh) signaling pathway that is involved in promoting cell growth, differentiation and tissue patterning in embryonic development. GLI1 over-activation and its nuclear localization has also… read more here.
Keywords: localization sequence; nuclear localization; gli1; site ... See more keywords
Evidence of a negative feedback network between TDP-43 and miRNAs dependent on TDP-43 nuclear localization.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.10.029
Abstract: TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that is integral to RNA processing. Among these functions is a critical role in microRNA (miRNA) biogenesis through interactions with the DROSHA and DICER complexes. It… read more here.
Keywords: tdp; nuclear localization; feedback network; negative feedback ... See more keywords
C-terminal 20 residues of ORF3 protein of duck circovirus genotype 2 regulates the nuclear localization and inhibits apoptotic activity of ORF3 protein.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2017.12.002
Abstract: Duck circovirus (DuCV) is divided into genotypes 1 and 2. The DuCV ORF3 protein is a newly identified viral protein with apoptotic activity. In this study, the differences in the gene sequences, subcellular localization, and… read more here.
Keywords: protein; nuclear localization; apoptotic activity; genotype ... See more keywords