Clinical Utility of the Nuclear-localized AR-V7 Biomarker in Circulating Tumor Cells in Improving Physician Treatment Choice in Castration-resistant Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "European urology"
DOI: 10.1016/j.eururo.2019.08.020
Abstract: BACKGROUND Proof of the clinical utility of a biomarker is when its use informs a management decision and improves patient outcomes relative to when it is not used. OBJECTIVE To model the clinical benefit of… read more here.
Keywords: nuclear localized; circulating tumor; tumor cells; prostate cancer ... See more keywords
Nuclear Localized O-fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-tune the Pace of Arabidopsis Circadian Clock.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular plant"
DOI: 10.1016/j.molp.2019.12.013
Abstract: Post-translational modifications play essential roles in finely modulating eukaryotic circadian clock systems. In plants, the effects of O-glycosylation on the circadian clock and the underlying mechanisms remain largely unknown. O-fucosyltransferase SPINDLY (SPY), and O-GlcNAc transferase… read more here.
Keywords: fucosyltransferase; spy; prr5; circadian clock ... See more keywords
Here, There, and Everywhere: Plastid- and Nuclear-Localized WHIRLY1 Regulates Salicylic Acid Homeostasis during Developmental Senescence
Sign Up to like & getrecommendations! Published in 2020 at "Plant Physiology"
DOI: 10.1104/pp.20.01475
Abstract: Does a new job always come with a new location? Perhaps this is true for some plant proteins; half of the proteins are located in more than one subcellular compartment. Emerging evidence in plants shows… read more here.
Keywords: localized whirly1; plastid nuclear; regulates salicylic; everywhere plastid ... See more keywords
Validation of nuclear-localized AR-V7 on circulating tumor cells (CTC) as a treatment-selection biomarker for managing metastatic castration-resistant prostate cancer (mCRPC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.273
Abstract: 273Background: A previous analysis of 161 patients (pts) tested for nuclear-localized AR-V7(+) CTCs showed a therapy interaction between AR-V7 positivity and improved overall survival (OS) on taxane chemotherapy vs. androgen receptor signaling inhibitors (ARSI). To… read more here.
Keywords: therapy interaction; biomarker; selection; nuclear localized ... See more keywords