Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts.
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DOI: 10.1038/s41551-021-00709-w
Abstract: Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury. Using fibroblasts from porcine aortic valves cultured on hydrogels… read more here.
Keywords: nuclear mechanosensing; chromatin remodelling; activated fibroblasts; persistently activated ... See more keywords